Related Experiment Video

Updated: Jul 30, 2025

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology
07:04

Identifying PD-1/PD-L1 Inhibitors with Surface Plasmon Resonance Technology

Published on: May 2, 2025

455

Inside PD-1/PD-L1,2 with their inhibitors

Nicolas Boisgerault1, Philippe Bertrand2

  • 1Nantes Université, Inserm UMR 1307, CNRS UMR 6075, Université D'Angers, CRCI2NA, LabEx IGO, F-44000, Nantes, France.

European Journal of Medicinal Chemistry
|May 17, 2023
PubMed

Insights

This review covers advancements in immune checkpoint inhibitors, focusing on both antibody-based therapies and small molecule drugs for enhanced cancer treatment strategies.

Area of Science:

  • Immunology
  • Pharmacology
  • Oncology

Background:

  • Immune checkpoint inhibitors (ICIs) have revolutionized cancer therapy.
  • Understanding their development is crucial for advancing treatment.

Purpose of the Study:

  • To review the current state of immune checkpoint inhibitor development.
  • To cover both antibody and small molecule approaches.

Main Methods:

  • Literature review of recent studies on immune checkpoint inhibitors.
  • Analysis of antibody-based and small molecule drug development.

Main Results:

  • Significant progress has been made in developing novel ICIs.
  • Both antibody and small molecule modalities show promise.

Conclusions:

  • Continued research into immune checkpoint inhibitors is vital.
  • Development of both antibodies and small molecules will expand therapeutic options.

Keywords:
Immune check pointInhibitorsPD-L1PD-L2PD1

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