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Static Adhesion Assay for the Study of Integrin Activation in T Lymphocytes
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Intercellular Adhesion Molecule 1: More than a Leukocyte Adhesion Molecule

Cameron D Haydinger1, Liam M Ashander1, Alwin Chun Rong Tan1

  • 1College of Medicine and Public Health, Flinders University, Adelaide, SA 5042, Australia.

Biology
|May 27, 2023
PubMed

Insights

Intercellular adhesion molecule 1 (ICAM-1) is a key immune protein involved in cell adhesion and migration. This review details ICAM-1

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • Intercellular adhesion molecule 1 (ICAM-1) is an immunoglobulin superfamily transmembrane protein.
  • ICAM-1 is expressed on various cell types and upregulated by inflammation.
  • It mediates cell adhesion by binding to integrins like LFA-1 and Mac-1.

Purpose of the Study:

  • To review the structure and regulation of the ICAM1 gene and ICAM-1 protein.
  • To discuss the roles of ICAM-1 in normal immune function.
  • To explore ICAM-1's involvement in diverse disease pathologies.

Main Methods:

  • Literature review of existing research on ICAM-1.
  • Synthesis of information on ICAM-1 structure, regulation, and function.
  • Analysis of ICAM-1's role in various diseases.

Main Results:

  • ICAM-1 plays critical roles in leukocyte adhesion, migration, and immune cell interactions.
  • ICAM-1 is implicated in the pathophysiology of cardiovascular diseases, autoimmune disorders, infections, and cancer.
  • ICAM-1 exhibits a dual role, contributing to both normal immune responses and disease progression.

Conclusions:

  • ICAM-1 is a multifaceted protein with significant implications in health and disease.
  • Understanding ICAM-1's complex functions is crucial for therapeutic development.
  • Further research into ICAM-1 therapeutics holds promise for treating various conditions.

Keywords:
ICAM-1atherosclerosiscancerimmune systeminfectioninflammationintercellular adhesion molecule 1

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