Related Experiment Video

Updated: Jul 27, 2025

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

5.5K

What is new about primary cutaneous B cell lymphomas

Maël Blanchard1,2, Wolfram Hoetzenecker3, Gabriela Blanchard1,2

  • 1Department of Dermatology and Venereology, Lausanne University Hospital (CHUV), Lausanne, Switzerland.

Italian Journal of Dermatology and Venereology
|June 6, 2023
PubMed

Insights

This review details the 2022 World Health Organization classification of primary cutaneous B-cell lymphomas (CBCL), distinguishing indolent from aggressive subtypes. Further research is vital for refining CBCL management and guidelines.

Area of Science:

  • Hematology
  • Dermatology
  • Oncology

Background:

  • Primary cutaneous B-cell lymphomas (CBCL) are a diverse group of lymphomas affecting the skin.
  • The 2022 World Health Organization classification refines the categorization of CBCL subtypes.

Purpose of the Study:

  • To review the clinical, cellular, and molecular characteristics of the five CBCL subtypes.
  • To discuss current management and treatment strategies for CBCL.
  • To highlight the need for further research in CBCL.

Main Methods:

  • Literature review of recent scientific advances.
  • Analysis of the 2022 World Health Organization classification of mature lymphoid neoplasms.
  • Synthesis of information on clinical, cellular, and molecular features, management, and treatment.

Main Results:

  • The 2022 classification distinguishes indolent CBCL (marginal zone, follicle center lymphoma, EBV-positive mucocutaneous ulcer) from aggressive CBCL (diffuse large B-cell lymphoma, leg-type, intravascular large B-cell lymphoma).
  • Understanding of CBCL entities has advanced significantly.
  • New treatments for systemic B-cell lymphomas offer hope for CBCL.

Conclusions:

  • Accurate classification of CBCL is essential for appropriate management.
  • High-quality prospective research is crucial to update international guidelines for CBCL.
  • Translating advances in systemic lymphoma treatment to CBCL requires specific investigation.

More Related Videos

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma15:07

VDJ-Seq: Deep Sequencing Analysis of Rearranged Immunoglobulin Heavy Chain Gene to Reveal Clonal Evolution Patterns of B Cell Lymphoma

Published on: December 28, 2015

26.7K
Enhancing Tumor Content through Tumor Macrodissection10:04

Enhancing Tumor Content through Tumor Macrodissection

Published on: February 12, 2022

10.2K

Related Concept Videos

Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
1.7K
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
1.7K