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LACC1: A critical involvement in macrophage immunometabolism
Yaling Li1, Zhixiong Wu1, Xiaoli Tan1
1Zhuzhou Central Hospital, Zhuzhou, Hunan, China.
Insights
Laccase domain-containing 1 (LACC1) is an enzyme in inflammatory macrophages. Targeting LACC1 offers a potential therapy for inflammatory and infectious diseases.
Area of Science:
- Immunology
- Enzymology
- Metabolic pathways
Background:
- Laccase domain-containing 1 (LACC1) protein is highly expressed in inflammatory macrophages.
- LACC1 plays a significant role in inflammatory bowel disease, arthritis, and microbial infections.
Purpose of the Study:
- This review focuses on LACC1-mediated catalysis.
- To elucidate the role of LACC1 in inflammation and immunity.
Main Methods:
- Review of existing literature on LACC1 function.
- Analysis of LACC1's enzymatic activity and its downstream effects.
Main Results:
- LACC1 catalyzes the conversion of l-citrulline (l-CIT) to l-ornithine (l-ORN) and isocyanic acid in mice and humans.
- LACC1 acts as a crucial link between nitric oxide synthase 2 (NOS2) and polyamine immunometabolism.
- LACC1 exhibits both anti-inflammatory and antibacterial properties.
Conclusions:
- LACC1's enzymatic activity and regulatory role highlight its importance in immune responses.
- Targeting LACC1 presents a promising therapeutic strategy for managing inflammatory and infectious diseases.
Abstract:
Laccase domain-containing 1 (LACC1) protein is an enzyme highly expressed in inflammatory macrophages, and studies have shown that it has a key role in diseases such as inflammatory bowel disease, arthritis, and microbial infections. Therefore, in this review, we focus on LACC1-mediated catalysis. In detail, LACC1 converts l-CITrulline (l-CIT) to l-ORNithine (l-ORN) and isocyanic acid in mice and humans and acts as a bridge between proinflammatory nitric oxide synthase (NOS2) and polyamine immunometabolism, thus exerting anti-inflammatory and antibacterial effects. Considering the actions of LACC1, targeting LACC1 may be a potent therapeutic avenue for inflammation-related diseases and microbial infection diseases.
