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Updated: Jul 23, 2025

Screening Assays to Characterize Novel Endothelial Regulators Involved in the Inflammatory Response
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ICAM-1 and VCAM-1: Gatekeepers in various inflammatory and cardiovascular disorders

Varinder Singh1, Rupinder Kaur1, Pratima Kumari1

  • 1Chitkara College of Pharmacy, Chitkara University, Punjab, India.

Clinica Chimica Acta; International Journal of Clinical Chemistry
|July 13, 2023
PubMed

Insights

Intercellular adhesion molecule 1 (ICAM-1) and Vascular cell adhesion molecule 1 (VCAM-1) are key in leukocyte adhesion and migration during inflammation and disease. Understanding their combined function offers insights into immune regulation and cardiovascular impacts, including during COVID-19.

Area of Science:

  • Immunology
  • Cell Biology
  • Pathophysiology

Background:

  • Leukocyte migration is vital for immune responses and tissue homeostasis.
  • Intercellular adhesion molecule 1 (ICAM-1) and Vascular cell adhesion molecule 1 (VCAM-1) mediate leukocyte adhesion to endothelial cells.
  • These molecules play critical roles in both acute and chronic inflammatory diseases.

Purpose of the Study:

  • To review the pathophysiological roles of ICAM-1 and VCAM-1 in various diseases.
  • To explore their emerging cardiovascular role, particularly in the context of the COVID-19 pandemic.
  • To highlight the potential of integrating membrane-bound and soluble forms for a comprehensive understanding.

Main Methods:

  • Literature review focusing on ICAM-1 and VCAM-1.
  • Analysis of their involvement in inflammatory and pathological conditions.
  • Examination of their cardiovascular implications, including during viral infections.

Main Results:

  • ICAM-1 and VCAM-1 are crucial for leukocyte recruitment and migration.
  • Dysregulation of these molecules is implicated in numerous diseases like cancer, atherosclerosis, and kidney diseases.
  • Their role in cardiovascular pathology and during COVID-19 is increasingly recognized.

Conclusions:

  • ICAM-1 and VCAM-1 are central players in inflammatory processes and disease pathogenesis.
  • Further research into their combined functional system is warranted.
  • Their significance extends to cardiovascular health and infectious disease impacts.

Keywords:
COVID-19CardiovascularICAM-1InflammationLeukocytesMigrationVCAM-1

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