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Interleukin 24: Signal Transduction Pathways

Simira Smith1, Sual Lopez1, Anastassiya Kim2

  • 1Department of Biological Sciences, Herbert H. Lehman College, City University of New York, 250 Bedford Park Boulevard West, Bronx, NY 10468, USA.

Cancers
|July 14, 2023
PubMed

Insights

Interleukin 24 (IL-24) has vital roles in immunity and inflammation. This review details IL-24

Area of Science:

  • Immunology
  • Molecular Biology
  • Cell Biology

Background:

  • Interleukin 24 (IL-24), part of the IL-10 family, is involved in antitumor responses, immune regulation, and inflammation.
  • IL-24 is produced by various cell types and signals through canonical and noncanonical pathways.
  • Understanding IL-24 signaling is crucial for therapeutic targeting.

Purpose of the Study:

  • To review the canonical and noncanonical signaling pathways of Interleukin 24.
  • To highlight the molecular interactions involved in IL-24 signal transduction.
  • To provide insights into the therapeutic potential of targeting IL-24.

Main Methods:

  • Literature review of studies on Interleukin 24 signaling.
  • Analysis of canonical JAK/STAT and noncanonical pathways.
  • Discussion of IL-24 interactions with receptors and intracellular proteins.

Main Results:

  • Canonical IL-24 signaling involves IL-20 receptors and JAK/STAT activation.
  • Noncanonical pathways include interactions with Protein Kinase R, mitochondrial proteins, and Sigma 1 Receptor.
  • Both canonical and noncanonical pathways contribute to IL-24's diverse functions.

Conclusions:

  • IL-24 utilizes complex and diverse signaling mechanisms.
  • Further elucidation of these pathways is essential for developing IL-24-based therapies.
  • Targeting IL-24 signaling holds promise for treating various diseases.

Keywords:
BiP/GRP78Grim 19JAK/STATPERKPKAPKRROSUTRceramideeIF2 alphaeIF4F complexinterleukin 10interleukin 20interleukin 24p38 MAPKsigma 1 receptortranslation regulationtumor necrosis factor-alpha

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