Related Experiment Video

Updated: Jul 17, 2025

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling
09:08

Isolating Human Peripheral Blood Mononuclear Cells and CD4+ T cells from Sézary Syndrome Patients for Transcriptomic Profiling

Published on: October 14, 2021

5.5K

Primary cutaneous marginal zone lymphoma presenting with secondary chilblains of the toes

Ali Zagham Nasir1, Ryan Scott Burmeister2

  • 1Internal Medicine Residency, Trinity Health Saint Mary's - Grand Rapids, Grand Rapids, Michigan, USA ali.nasir@trinity-health.org.

BMJ Case Reports
|August 28, 2023
PubMed

Insights

Primary cutaneous marginal zone lymphoma (PCMZL) can manifest as chilblains. Early diagnosis via skin biopsy and treatment with rituximab can lead to resolution of these refractory dermatological symptoms.

Area of Science:

  • Dermatology
  • Hematology
  • Oncology

Background:

  • Cutaneous lymphoproliferative disorders encompass systemic lymphoma manifestations and primary cutaneous lymphomas.
  • Primary cutaneous B-cell lymphomas are classified into four types, including primary cutaneous marginal zone lymphoma (PCMZL).
  • Accurate diagnosis and staging are crucial for effective treatment of these conditions.

Observation:

  • A case of PCMZL presented atypically as secondary chilblains on the toes.
  • Diagnosis was confirmed through a punch skin biopsy.
  • The patient's chilblains resolved completely following treatment with rituximab.

Findings:

  • This case highlights PCMZL as a potential cause of refractory chilblains.
  • Skin biopsy is essential for diagnosing cutaneous lymphoproliferative disorders.
  • Rituximab demonstrated efficacy in treating this manifestation of PCMZL.

Implications:

  • Clinicians should consider PCMZL in the differential diagnosis of patients with persistent chilblains or skin lesions.
  • Early recognition and appropriate biopsy can lead to timely diagnosis of primary cutaneous lymphomas.
  • This case broadens the understanding of PCMZL's clinical presentations and treatment responses.

Keywords:
DermatologyOncologyRheumatologySkin cancer

More Related Videos

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

11.2K
Granulocyte-dependent Autoantibody-induced Skin Blistering12:23

Granulocyte-dependent Autoantibody-induced Skin Blistering

Published on: October 12, 2012

10.6K

Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
3.9K
Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation01:21

Peripheral Arterial Disease II: Clinical Manifestations and Diagnostic Evaluation

Clinical manifestationsPeripheral Arterial Disease (PAD) manifests through a range of symptoms, from the characteristic intermittent claudication to atypical presentations and severe complications in advanced stages. Intermittent claudication, a hallmark symptom of PAD, presents as exercise-induced muscle pain that typically resolves within minutes of rest. This pain is reproducible and stems from inadequate blood flow, leading to the accumulation of lactic acid produced during anaerobic...
17
Endocarditis II: Clinical Features of Infective Endocarditis01:25

Endocarditis II: Clinical Features of Infective Endocarditis

Endocarditis can present various clinical features depending on the causative organism and the patient's underlying health conditions. Initially, the clinical features of infective endocarditis develop gradually, presenting with nonspecific symptoms that can be easily mistaken for other illnesses.General SymptomsEarly symptoms of infective endocarditis are fever, chills, weakness, malaise, fatigue, and weight loss. These symptoms reflect the systemic nature of the infection and the body's...
14
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...
1.6K
Skin Cancer01:30

Skin Cancer

Skin cancer is a type of cancer that occurs when there is an abnormal growth of skin cells, usually triggered by damage to the DNA within the skin cells. It is primarily caused by exposure to ultraviolet (UV) radiation from the sun or artificial sources like tanning beds. Skin cancer is the most common type of cancer worldwide, and its incidence continues to rise.
Basal Cell Carcinoma (BCC): BCC is the most common type of skin cancer, accounting for about 80% of cases. It typically develops in...
4.2K
Pulmonary Tuberculosis III01:31

Pulmonary Tuberculosis III

Tuberculosis (TB) is a contagious infection primarily affecting the lung parenchyma but which can also affect other body parts. TB can be classified based on disease development, presentation, and the affected anatomical site.
The first classification is based on the development of the disease, and it includes the following categories:
363