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Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
Published on: January 9, 2019
Diagnosing Lymphoma on Core Needle Biopsy and the Challenging Role of Immunohistochemistry
1Department of Pathology and Laboratory Medicine, King Faisal Specialist Hospital and Research Center, Jeddah, SAU.
Insights
This study reviews novel immunohistochemistry (IHC) markers and applications for diagnosing lymphomas, particularly on small biopsy samples. These advancements aid hematopathologists in challenging cases, improving lymphoma diagnosis and treatment strategies.
Area of Science:
- Hematopathology
- Oncology
- Immunohistochemistry
Background:
- Lymphoma diagnosis faces challenges due to updated classifications and reliance on small biopsy samples.
- Immunohistochemistry (IHC) is crucial for accurate hematopathology diagnosis.
- There is a growing need for improved diagnostic tools in lymphoma assessment.
Purpose of the Study:
- To provide hematopathologists with an overview of novel and established immunohistochemistry markers for lymphoma diagnosis.
- To highlight the utility of IHC in diagnosing lymphomas, especially from core needle biopsies.
- To enhance the understanding of evolving IHC applications in hematolymphoid neoplasms.
Main Methods:
- Comprehensive literature review of recent advancements in lymphoma immunohistochemistry.
- Inclusion of personal experience from professional practice in hematopathology.
- Focus on novel markers and new applications of existing IHC markers.
Main Results:
- Introduction of new immunohistochemistry markers relevant to lymphoma diagnosis.
- Discussion of updated applications for established IHC markers.
- Emphasis on the diagnostic value of IHC in limited tissue samples.
Conclusions:
- Novel IHC markers and applications are essential for accurate lymphoma diagnosis.
- IHC plays a critical role in overcoming diagnostic challenges posed by small biopsy samples.
- Enhanced understanding of IHC aids in the timely and effective treatment of hematolymphoid neoplasms.
Abstract:
Publications and primary literature both describe the latest advancements in immunohistochemical diagnosis of lymphomas. Along with the updated categorizations, the growing reliance on small biopsy samples to assess lymphoma poses a constant difficulty in hematopathology diagnosis and heightens the demand for immunohistochemistry (IHC). This study aimed to provide practicing lymphoma and hematopathologists with an overview of novel immunohistochemical markers and new applications of already established immunohistochemistry markers to be helpful in lymphoma diagnosis, especially in core needle biopsies. The information was sourced from a review of relevant literature and personal experience gained through professional practice. To effectively diagnose and treat hematolymphoid neoplasms, we need to have a comprehensive understanding of the constantly evolving range of immunohistochemistry studies. This article introduced new markers that contribute to our overall knowledge of the disease, diagnosis, and treatment. The addition of these markers might be helpful in supporting the tumor diagnosis on limited sample material obtained from needle biopsies.
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