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Lymphomatosis Cerebri: A diagnostic dilemma
Sibgha Khan1, Fatima Mubarak1, Khurram Minhas1
1Department of Radiology, Aga Khan University Hospital, National Stadium Road, Karachi, Pakistan.
Insights
Lymphomatosis cerebri (LC), a rare diffuse infiltration of primary central nervous system lymphoma (PCNSL), presents diagnostic challenges. This case highlights the importance of recognizing LC
Area of Science:
- Neuro-oncology
- Neuropathology
Background:
- Lymphomatosis cerebri (LC) is a rare, diffuse infiltrating manifestation of primary central nervous system lymphoma (PCNSL).
- It typically originates from B-cell non-Hodgkin's lymphoma.
- Few cases are reported, often mimicking other conditions.
Observation:
- A 53-year-old male presented with seizures and postictal confusion.
- Multiple MRI scans were performed, and a biopsy initially suggested infection.
- Treatment for infection yielded no improvement.
Findings:
- Review of imaging raised suspicion for LC.
- Histopathology review confirmed primary CNS lymphoma.
- The case presented a diagnostic challenge due to initial misdiagnosis.
Implications:
- LC is an established but rare PCNSL variant.
- Accurate imaging interpretation is crucial for differentiating LC from other conditions.
- Timely diagnosis of LC is essential for appropriate treatment and patient outcomes.
Background:
Lymphomatosis cerebri (LC) is a rare manifestation of primary central nervous system lymphoma (PCNSL) with only a few cases reported in the literature, appearing as diffuse infiltrating process rather than a solitary mass. It is a non-Hodgkin's type of lymphoma and is usually of the B-cell type origin.
Purpose:
We intend to report this unique case of LC which came across as a diagnostic challenge.
Methods:
A 53-year-old gentleman presented with complaints of two episodes of seizures 24 h apart followed by postictal confusion for 10-15 min. He underwent multiple MRI scans and underwent a biopsy of the lesion which reported infection, but he did not benefit from the treatment.
Result:
The imaging was reviewed, suspicion of LC was raised and a review of histopathology was requested which later confirmed primary CNS lymphoma.
Conclusion:
LC is a rare but established manifestation of PCNSL which mimics multiple other conditions. Understanding of the imaging pattern is important in making the diagnosis and differentiating it from other mimic conditions.
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