Related Experiment Video

Updated: Jun 20, 2025

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions
05:58

Preparation of Single-cell Suspensions for Cytofluorimetric Analysis from Different Mouse Skin Regions

Published on: April 20, 2016

18.4K

Langerhans cells and skin immune diseases

Ronghui Zhu1,2,3, Xu Yao4, Wei Li1

  • 1Department of Dermatology, Shanghai Institute of Dermatology, Huashan Hospital, Fudan University, Shanghai, P. R. China.

European Journal of Immunology
|July 20, 2024
PubMed

Insights

Human Langerhans cells (LCs) are crucial skin immune cells. Recent single-cell studies reveal their complex roles in inflammatory skin diseases, offering new therapeutic targets.

Area of Science:

  • Immunology
  • Dermatology
  • Cell Biology

Background:

  • Langerhans cells (LCs) are key epidermal antigen-presenting cells.
  • LCs modulate immune responses, exhibiting both pro- and anti-inflammatory effects.
  • Traditional LC research relied on mouse models, limiting human-specific insights.

Purpose of the Study:

  • To review recent advancements in understanding human Langerhans cells.
  • To summarize the function of LCs in inflammatory skin diseases.
  • To propose strategies for precise LC modulation in dermatological treatments.

Main Methods:

  • Review of current scientific literature.
  • Analysis of single-cell studies on human LCs.
  • Synthesis of data on LC phenotype, ontogeny, differentiation, and function.

Main Results:

  • Single-cell technologies have significantly advanced human LC research.
  • Human LCs exhibit diverse phenotypes and functions.
  • LCs play a critical role in the pathogenesis of various inflammatory skin conditions.

Conclusions:

  • Understanding human LCs is crucial for dermatology.
  • Precise regulation of LC function holds therapeutic potential for skin diseases.
  • Future research should focus on translating human LC knowledge into clinical applications.

Keywords:
Atopic dermatitisHumanImmune responseLangerhans cellsLupus erythematosusPsoriasis

More Related Videos

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture10:31

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Published on: April 8, 2016

14.5K
Isolation of Infiltrating Leukocytes from Mouse Skin Using Enzymatic Digest and Gradient Separation07:11

Isolation of Infiltrating Leukocytes from Mouse Skin Using Enzymatic Digest and Gradient Separation

Published on: January 25, 2016

21.4K

Related Concept Videos

Skin Diseases and Disorders01:23

Skin Diseases and Disorders

Skin is the first line of defense and encounters a variety of microbes. Some pathogenic strains are often the cause of a broad range of infections of the skin and other body systems. These conditions can affect people of all ages and may have different causes, including genetic factors, infections, autoimmune reactions, environmental factors, and lifestyle choices.
Gram-positive Staphylococcus spp. and Streptococcus spp. are responsible for many of the most common skin infections. However, many...
3.8K
Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
68.0K
T Cell Types and Functions01:24

T Cell Types and Functions

When T cells with CD4 markers are activated, they give rise to two types of effector cells: helper T cells and regulatory T cells. Meanwhile, T cells with CD8 markers differentiate into effector cytotoxic T cells. The differentiation of CD4 T cells into helper T cell subsets, such as Th1, Th2, and Th17 cells, is dependent on the antigen type, antigen-presenting cell, and regulatory cytokines.
Th1 cells stimulate dendritic cells to express necessary co-stimulatory molecules on their surfaces for...
990
Antigens Involved in Adaptive Immunity01:26

Antigens Involved in Adaptive Immunity

An antigen is any substance the immune system identifies as foreign and potentially harmful to the body, prompting an immune response. Antigens have two functional properties: immunogenicity and reactivity. Immunogenicity is the ability of an antigen to stimulate a specific immune response. At the same time, reactivity describes the antigen's ability to react with the cells and antibodies produced in response to it.
Complete Antigens
Complete antigens possess both immunogenicity and...
482
Cells of the Adaptive Immune Response01:23

Cells of the Adaptive Immune Response

The T and B lymphocytes of the adaptive immune system develop from common lymphoid progenitor cells in the bone marrow. These progenitors give rise to precursors that eventually develop into both T and B lymphocytes. As these precursors mature, they gain the ability to detect and respond to foreign antigens in the body, a process known as immunocompetence. Additionally, these precursors acquire self-tolerance, a process that ensures they do not react to self-antigens. This intricate system...
977
What is the Immune System?01:38

What is the Immune System?

Overview
111.1K