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Multimodality Radiologic and Pathologic Findings in Large B-cell Lymphoma With Hepatic Presentation in an Unusually

Konrad Drzymalski1, Alexandria Sobczak1, Brianna Castellano1

  • 1Medicine, Dr. Kiran C. Patel College of Osteopathic Medicine, Nova Southeastern University, Fort Lauderdale, USA.

Cureus
|September 16, 2024
PubMed

Insights

This case report details a rare presentation of Diffuse Large B-cell Lymphoma (DLBCL) in a young African American male with initial liver and spleen involvement. Early suspicion of DLBCL is crucial for atypical extranodal presentations to improve patient outcomes.

Area of Science:

  • Oncology
  • Hematology
  • Clinical Case Reports

Background:

  • Diffuse Large B-cell Lymphoma (DLBCL) is the most common non-Hodgkin lymphoma (NHL).
  • Typical DLBCL presentation involves patients over 60 with gastrointestinal tract involvement.
  • Demographic norms for DLBCL usually exclude young adults and atypical hepatic involvement.

Observation:

  • A 27-year-old African American male presented with abdominal distention.
  • Imaging revealed hepatosplenomegaly with liver and spleen nodular lesions.
  • Biopsy confirmed the diagnosis of DLBCL.

Findings:

  • The patient's presentation was atypical due to his young age, race, and initial hepatic involvement.
  • This case highlights a rare clinical manifestation of DLBCL.
  • The findings underscore the variability in DLBCL presentation.

Implications:

  • Clinicians should consider DLBCL in younger patients with unusual extranodal organ involvement.
  • Maintaining a high index of suspicion for DLBCL is vital for atypical cases.
  • Prompt diagnosis and management of DLBCL in atypical presentations can optimize patient outcomes.

Keywords:
clinical case reportextranodal diffuse large b-cell lymphomahepatic lymphomalarge b cell lymphomanon-hodgkins lymphoma

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