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Updated: Jun 13, 2025

Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions
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Assay of Adhesion Under Shear Stress for the Study of T Lymphocyte-Adhesion Molecule Interactions

Published on: June 29, 2016

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Intercellular adhesion molecule-1 (ICAM-1): From molecular functions to clinical applications in cancer investigation

Wen-Jing Qian1, Jin-Shan Yan2, Xiao-Yu Gang2

  • 1Department of Pathology, Zhongshan Hospital, Fudan University, Shanghai 200032, China.

Biochimica Et Biophysica Acta. Reviews on Cancer
|September 24, 2024
PubMed

Insights

Intercellular adhesion molecule-1 (ICAM-1) has a dual role in cancer, boosting antitumor immunity while also aiding tumor evasion and metastasis. Research explores anti-ICAM-1 therapies for improved cancer treatment outcomes.

Area of Science:

  • Oncology
  • Immunology
  • Molecular Biology

Background:

  • Intercellular adhesion molecule-1 (ICAM-1) is a key molecule in cellular interactions.
  • ICAM-1 exhibits a bidirectional role in tumor development, influencing both antitumor immunity and tumor progression.

Purpose of the Study:

  • To review recent advancements in understanding ICAM-1's role in tumor development.
  • To explore ICAM-1's relevance in predicting therapeutic efficacy and prognosis.
  • To summarize progress in clinical translational research on anti-ICAM-1-based therapies.

Main Methods:

  • Comprehensive literature review of ICAM-1 in cancer.
  • Analysis of ICAM-1's involvement in immune cell migration, tumor evasion, and metastasis.
  • Evaluation of clinical data for anti-ICAM-1 therapies.

Main Results:

  • ICAM-1 enhances antitumor immune responses through immune cell recruitment and synapse formation.
  • ICAM-1 promotes tumor immune evasion, metastasis via transendothelial migration and EMT, and epigenetic modifications.
  • Clinical research is advancing for anti-ICAM-1 therapies including monoclonal antibodies, immunotherapy, and antibody-drug conjugates.

Conclusions:

  • ICAM-1 is a significant and versatile target for cancer treatment.
  • Further research and clinical translation of anti-ICAM-1 strategies are crucial for enhancing cancer therapy.
  • Targeting ICAM-1 holds promise for improving patient prognosis and therapeutic efficacy.

Keywords:
ImmunologyInflammationIntercellular adhesion molecule-1 (ICAM-1)MetastasisTherapeutic targets

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