Related Experiment Video

Updated: Sep 13, 2025

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226
08:30

Isolation of Group 2 Innate Lymphoid Cells from Mouse Nasal Mucosa to Detect the Expression of CD226

Published on: May 10, 2022

2.0K

The Immune Regulatory Functions of CD226 and Its Implications in Immune-Mediated Diseases

Keyan Liu1, Yuanzhen Liu2, Huabao Xiong2

  • 1Department of Public Health, Jining Medical University, Jining 272067, China.

Biomolecules
|July 29, 2025
PubMed

Insights

CD226 regulates immune cell function and is implicated in various diseases. Understanding CD226

Area of Science:

  • Immunology
  • Molecular Biology
  • Cellular Biology

Background:

  • CD226, an immunoglobulin superfamily member, is a key regulator of immune responses.
  • Predominantly expressed on natural killer (NK) cells and T cells, CD226 interacts with ligands CD155 and CD112.
  • This interaction influences T cell differentiation, effector functions, and NK cell activation and cytotoxicity.

Purpose of the Study:

  • To review the current understanding of CD226's role in immune responses.
  • To outline CD226's involvement in various immunological diseases.
  • To provide insights for future research on CD226's role in disease pathogenesis.

Main Methods:

  • Literature review of existing research on CD226.
  • Analysis of genetic polymorphisms and expression patterns of CD226.
  • Synthesis of data on CD226's function in immune cells and disease contexts.

Main Results:

  • CD226 plays a critical role in modulating T cell and NK cell functions.
  • Dysregulated CD226 expression and genetic variations are linked to autoimmune, infectious, allergic diseases, and cancer.
  • CD226 is identified as a promising therapeutic target for immune-mediated diseases.

Conclusions:

  • CD226 is a crucial molecule in immune regulation with significant implications in disease.
  • Further research into CD226 mechanisms can advance therapeutic strategies for immune-mediated conditions.
  • This review consolidates current knowledge on CD226's multifaceted roles in immunity and disease.

Keywords:
CD226autoimmune diseasesimmune regulationinfectious diseasestumor immunity

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