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[A Case of Primary Breast Diffuse Large B-Cell Lymphoma in a Male Patient]

Hanae Matsuda1, Masae Miyashita, Kazuo Tanaka

  • 1Dept. of Breast Surgery, Ishikiriseiki Hospital.

Gan to Kagaku Ryoho. Cancer & Chemotherapy
|May 25, 2026
PubMed

Insights

A 68-year-old man was diagnosed with primary breast diffuse large B-cell lymphoma (DLBCL). Treatment involved surgical resection followed by polatuzumab vedotin and R-CHP chemotherapy.

Area of Science:

  • Oncology
  • Hematology
  • Medical Imaging

Background:

  • Primary breast lymphoma is a rare condition.
  • Diffuse large B-cell lymphoma (DLBCL) can manifest in the breast.
  • Early diagnosis and appropriate treatment are crucial for patient outcomes.

Purpose of the Study:

  • To report a case of primary breast DLBCL.
  • To describe the diagnostic process including imaging and biopsy.
  • To outline the treatment strategy including surgery and chemotherapy.

Main Methods:

  • A 68-year-old male patient presented with a breast mass.
  • Diagnostic workup included breast ultrasonography, core needle biopsy (CNB), positron emission tomography-computed tomography (PET-CT), and bone marrow examination.
  • Treatment consisted of surgical resection followed by polatuzumab vedotin and R-CHP (Pola + R-CHP) chemotherapy.

Main Results:

  • Ultrasonography showed an irregular hypoechoic mass.
  • CNB confirmed diffuse large B-cell lymphoma (DLBCL).
  • Staging investigations revealed no extranodal involvement, confirming primary breast DLBCL. The patient underwent surgery and chemotherapy.

Conclusions:

  • Primary breast DLBCL is a rare but treatable malignancy.
  • Multimodality treatment including surgery and chemotherapy (Pola + R-CHP) can be effective.
  • This case highlights the importance of considering lymphoma in breast masses.

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