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Cryptococcosis mimicking lung cancer in an immunocompetent patient: A case report
Alejandro Hernández-Solís1, Alexandro Bonifaz2, Javier Araiza-Santibáñez3
1Head, Department of Pulmonology. General Hospital of Mexico "Dr Eduardo Liceaga", Mexico City, Mexico.
Insights
This case study highlights cryptococcosis in an immunocompetent host, presenting as lung nodules mimicking cancer. Prompt diagnosis and fluconazole treatment led to full recovery.
Area of Science:
- Medical Mycology
- Infectious Diseases
- Pulmonology
Background:
- Cryptococcosis typically affects immunocompromised individuals.
- Pulmonary cryptococcosis can mimic lung malignancy with nonspecific symptoms.
- Rare cases occur in immunocompetent hosts.
Abstract:
Cryptococcosis predominantly affects immunocompromised individuals, but cases have been reported in immunocompetent hosts. Pulmonary involvement often presents nonspecific features that could resemble lung malignancy. We present a case of a 49-year-old immunocompetent, HIV-negative, non-smoker man with progressive respiratory symptoms and significant weight loss. Imaging revealed multiple pulmonary nodules with mild metabolic activity. Non-invasive diagnostic studies were inconclusive. Histopathological examination of lung tissue demonstrated encapsulated yeasts consistent with Cryptococcus spp., confirmed by fungal culture and MALDI-TOF mass spectrometry. Later, cerebrospinal fluid analysis also showed encapsulated yeasts. The patient was treated successfully with fluconazole, achieving complete clinical and mycological remission.
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