Interleukin-10 in the vitreous of patients with primary intraocular lymphoma
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Updated: Aug 14, 2026
Intravitreal Injections in the Ovine Eye
Published on: July 5, 2022
C C Chan1, S M Whitcup, D Solomon
1Laboratory of Immunology, National Eye Institute, Bethesda, MD 20892-1858, USA.
Insights
Elevated levels of interleukin-10 in the vitreous fluid may aid in diagnosing primary intraocular lymphoma. This biomarker correlates with disease activity and malignant cell counts, offering a simple diagnostic clue.
Area of Science:
- Ophthalmology
- Oncology
- Immunology
Background:
- Primary intraocular lymphoma (IOL) is a rare malignancy.
- Accurate and timely diagnosis of IOL is crucial for effective treatment.
- Current diagnostic methods can be invasive or lack specificity.
Purpose of the Study:
- To identify a simple and accurate diagnostic marker for primary intraocular lymphoma.
- To evaluate the diagnostic utility of specific cytokine concentrations in vitreous fluid.
Main Methods:
- Prospective analysis of vitreous specimens from patients with IOL and uveitis.
- Enzyme-linked immunosorbent assay (ELISA) used to measure cytokine concentrations (interleukin-10, -1, -2, -4, -6).
Main Results:
- Interleukin-10 (IL-10) was detected in the vitreous of patients with primary intraocular lymphoma.
- IL-10 levels demonstrated a correlation with clinical disease activity.
- IL-10 concentrations also correlated with the number of malignant cells in vitreous samples.
Conclusions:
- Vitreous interleukin-10 (IL-10) concentration is a potential biomarker for diagnosing primary intraocular lymphoma.
- IL-10 measurement offers a valuable diagnostic clue for clinicians and pathologists.
- This cytokine analysis may simplify the diagnostic process for IOL.
Purpose:
To find an accurate and simple method to diagnose primary intraocular lymphoma.
Methods:
We prospectively analyzed concentrations of interleukin-10, interleukin-1, interleukin-2, interleukin-4, and interleukin-6 in vitrectomy specimens from three patients with primary intraocular lymphoma and five patients with uveitis by enzyme-linked immunosorbent assay.
Results:
Interleukin-10 in the vitreous was detected in patients with primary intraocular lymphoma. Interleukin-10 levels correlated with clinical activity and the number of malignant cells.
Conclusion:
Concentrations of interleukin-10 in the vitreous may be a helpful clue to both clinicians and pathologists in diagnosing primary intraocular lymphoma.
