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Lymphoplasmacyte-rich meningioma in a child. Case report
H Loiseau1, J M Pedespan, A Vital
1University Clinic of Neurosurgery, Hôpital Pellegrin, Bordeaux, France.
Insights
A rare pediatric meningioma with lymphoplasmacyte-rich features presented with seizures and blood chemistry abnormalities. Histology confirmed B lymphocyte infiltrates, highlighting poorly understood pathophysiology.
Area of Science:
- Neurology
- Oncology
- Immunology
Background:
- Meningiomas are typically benign tumors arising from the meninges.
- Lymphoplasmacyte-rich meningiomas are an uncommon subtype with distinct histological features.
- Understanding rare variants is crucial for accurate diagnosis and treatment.
Observation:
- A pediatric case of lymphoplasmacyte-rich meningioma is presented.
- Initial symptoms included seizures, with neuroradiology suggesting meningioma.
- Blood chemistry revealed hypergammaglobulinemia and inflammatory syndrome.
Findings:
- Histological confirmation of meningioma with significant B lymphocyte infiltration.
- The tumor exhibited massive infiltrates of type B lymphocytes.
- Associated peripheral blood abnormalities, including hypergammaglobulinemia, were noted.
Implications:
- The pathophysiology of lymphoplasmacyte infiltrates in meningiomas remains unclear.
- This case underscores the importance of considering differential diagnoses for meningioma-like masses.
- Further research is needed to elucidate the mechanisms behind these rare tumor variants.
Abstract:
A rare case of lymphoplasmacyte-rich meningioma observed in a young girl is reported. The first clinical manifestations of the disease were seizures. Neuroradiological images favored the existence of a meningioma. Abnormalities in the patient's blood chemistry, principally including hypergammaglobulinemia and inflammatory syndrome, were associated with the disease. The tumor was histologically confirmed as meningioma with massive infiltrates of type B lymphocytes. The pathophysiology of the conspicuous lymphoplasmacyte infiltrates, responsible for peripheral blood abnormalities, has remained poorly understood. Alternative diagnostic hypotheses of masses that mimic this type of meningioma are discussed.
