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[Physiopathological role of low affinity IgE receptor (CD23) in hematopoietic cells]

J P Kolb1, N Paul-Eugène, F Ouaaz

  • 1Unité INSERM U365, Institut Curie, Paris.

Comptes Rendus Des Seances De La Societe De Biologie Et De Ses Filiales
|January 1, 1994
PubMed

Insights

Signaling through the low-affinity IgE receptor (CD23) varies by cell type. Monocytes utilize a pathway involving nitric oxide synthase, which is amplified in allergic diseases, impacting immune cell function.

Area of Science:

  • Immunology
  • Cell Signaling

Context:

  • The low-affinity IgE receptor (CD23) plays a role in immune responses.
  • CD23 signaling pathways differ across cell types, influencing cellular functions.

Purpose:

  • To investigate the distinct signaling pathways triggered by CD23 ligation in B lymphocytes and monocytes.
  • To elucidate the role of CD23 signaling in monocyte differentiation and inflammatory responses.

Summary:

  • CD23 ligation in B cells activates phospholipase C and cAMP accumulation via a Pertussis toxin-insensitive G-protein.
  • In monocytes (CD23b isoform), CD23 ligation induces delayed cAMP accumulation dependent on cGMP and nitric oxide synthase activation.
  • This monocyte CD23 pathway is exacerbated in allergic diseases and affects cell differentiation, mediator release, and cytotoxicity.

Impact:

  • Understanding CD23 signaling in monocytes provides insights into allergic disease pathogenesis.
  • Identifies a novel pathway influencing monocytic lineage differentiation and inflammatory mediator release.
  • Highlights the potential of targeting CD23-mediated monocyte signaling in treating allergic conditions.

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