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Immunophysiology: the immune system as a multifunctional physiological unit

P Deschaux1, N A Khan

  • 1Faculté des Sciences de Limoges, Laboratoire d'Immunophysiologie, France.

Cellular & Molecular Biology Research
|January 1, 1995
PubMed

Insights

This review explores immunophysiology, detailing how the immune and endocrine systems communicate bidirectionally via hormones and cytokines. It proposes cellular models for this immune-endocrine cross-talk.

Area of Science:

  • Immunology
  • Endocrinology
  • Physiology

Background:

  • The immune system functions in concert with other organs, utilizing common receptors and cytokines for communication.
  • Bidirectional communication exists between the immune and endocrine systems, influencing each other's functions.

Purpose of the Study:

  • To review the concept of immunophysiology, emphasizing the interplay between the immune and endocrine systems.
  • To define the cellular mechanisms underlying immune-endocrine "cross-talk".

Main Methods:

  • Review of existing literature on neuroendocrine-immune interactions.
  • Proposal of one- and two-signal models to explain cellular communication pathways.

Main Results:

  • Hormones and neurohormones bind to lymphocytes, initiating signaling.
  • Antigen binding or cytokine receptor interactions on lymphocytes generate secondary signals, illustrating cross-talk.

Conclusions:

  • The physiological reality of immune-endocrine interrelationships is supported by proposed cellular signaling models.
  • Understanding immunophysiology is crucial for comprehending integrated bodily functions.

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