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Cytokine expression in large cell lymphoma associated with acquired immunodeficiency syndrome

J W Marsh1, B Herndier, A Tsuzuki

  • 1Department of Medicine, University of California, San Francisco 94110, USA.

Journal of Interferon & Cytokine Research : the Official Journal of the International Society for Interferon and Cytokine Research
|March 1, 1995
PubMed

Insights

Interleukin-6 (IL-6) and Interleukin-10 (IL-10) are implicated in the development of large cell lymphomas in patients with acquired immunodeficiency syndrome (AIDS). These cytokines may promote tumor growth through autocrine or paracrine signaling pathways.

Area of Science:

  • Oncology
  • Immunology
  • Virology

Background:

  • Acquired immunodeficiency syndrome (AIDS)-associated lymphomas are aggressive malignancies.
  • The role of specific cytokines in the pathogenesis of these lymphomas is not fully understood.

Purpose of the Study:

  • To investigate the expression of Interleukin-6 (IL-6) and Interleukin-10 (IL-10) in AIDS-associated large cell lymphomas (LCL).
  • To explore the potential autocrine or paracrine mechanisms involving these cytokines in lymphoma development.

Main Methods:

  • Retrospective analysis of 16 AIDS-associated LCL specimens.
  • Reverse transcriptase-polymerase chain reaction (RT-PCR) for cytokine expression analysis.
  • Immunoperoxidase staining and EBER in situ hybridization for cellular and viral detection.

Main Results:

  • IL-6 receptor (IL-6R) and IL-10 were detected in most tumor samples.
  • IL-6 expression was observed in a subset of lymphomas expressing IL-6R, suggesting autocrine IL-6 signaling.
  • HIV-infected macrophages expressing IL-6 were identified in mixed immunophenotype lymphomas, indicating potential paracrine IL-6 activity.
  • IL-10 expression was found in AIDS LCLs independently of Epstein-Barr virus (EBV) infection.

Conclusions:

  • IL-6 and IL-10 play a significant role in the pathogenesis of AIDS-associated large cell and mixed immunophenotype lymphomas.
  • Both autocrine and paracrine mechanisms involving IL-6 and IL-10 are likely involved in lymphoma growth.
  • IL-10 may function as an autocrine or paracrine growth factor for CD5-expressing AIDS LCLs.

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