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Updated: Aug 10, 2026

Simultaneous Isolation and Culture of Atrial Myocytes, Ventricular Myocytes, and Non-Myocytes from an Adult Mouse Heart
11:53

Simultaneous Isolation and Culture of Atrial Myocytes, Ventricular Myocytes, and Non-Myocytes from an Adult Mouse Heart

Published on: June 14, 2020

[Glandular myxoma of the heart]

B Sipos1, B Járay, T Richter

  • 1Semmelweis Orvostudományi Egyetem, Budapest.

Orvosi Hetilap
|June 18, 1995
PubMed

Insights

This study investigated a left atrial myxoma with glandular structures. Findings suggest these glands are mucin-secreting epithelial cells, offering insights into myxoma histogenesis.

Area of Science:

  • Cardiovascular Pathology
  • Surgical Pathology
  • Histology

Background:

  • Cardiac myxomas are primary tumors of the heart, typically located in the left atrium.
  • The histogenesis of cardiac myxomas remains incompletely understood, with various theories proposed.
  • Glandular differentiation within myxomas is an uncommon but recognized phenomenon.

Observation:

  • Microscopic examination revealed glandular lumina lined by cylindric epithelium within the myxoid stroma.
  • These glands contained periodic acid-Schiff (PAS) positive mucin.
  • Immunohistochemical analysis showed positivity for cytokeratins (CK), epithelial membrane antigen (EMA), and carcinoembryonic antigen (CEA).

Findings:

  • The glandular structures exhibited features consistent with mucin-secreting epithelium.
  • Stromal cells tested positive for vimentin and Factor VIII-related antigen (FVIII. Ag).
  • Ultrastructural analysis confirmed the epithelial nature and mucin-secreting capacity of the glandular components.

Implications:

  • The presence of mucin-secreting glands provides further evidence for diverse cellular origins or differentiation pathways in cardiac myxomas.
  • Understanding these glandular components may refine diagnostic criteria and contribute to elucidating myxoma histogenesis.
  • This detailed characterization aids in differentiating myxomas from other cardiac neoplasms.

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