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Updated: Aug 12, 2026

Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture
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Lymphocyte Isolation from Human Skin for Phenotypic Analysis and Ex Vivo Cell Culture

Published on: April 8, 2016

Epidermal Langerhans' cells and their function in the skin immune system

A D Hogan1, A W Burks

  • 1Department of Pediatrics, Arkansas Children's Hospital, University of Arkansas for Medical Science, Little Rock, USA.

Annals of Allergy, Asthma & Immunology : Official Publication of the American College of Allergy, Asthma, & Immunology
|July 1, 1995
PubMed

Insights

Langerhans

Area of Science:

  • Immunodermatology
  • Cell Biology

Background:

  • Epidermal Langerhans' cells are key immune cells in the skin.
  • Their role in allergic and inflammatory skin conditions is complex.

Purpose of the Study:

  • To review current knowledge on Langerhans' cell function.
  • To relate this function to allergic and immunologic diseases.

Main Methods:

  • Literature search of English publications from 1974-1994.
  • Indexing terms included Langerhans' cells, atopic dermatitis, and IgE.

Main Results:

  • Langerhans' cells possess diverse surface receptors and secrete cytokines.
  • Differences exist between freshly isolated and cultured Langerhans' cells.

Conclusions:

  • Langerhans' cells are central to immune responses in various skin diseases.
  • They are implicated in contact dermatitis, atopic dermatitis, histiocytosis X, HIV-1, and skin graft rejection.
Abstract

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