Related Experiment Video

Updated: Aug 12, 2026

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma
10:52

Tumor Engraftment in a Xenograft Mouse Model of Human Mantle Cell Lymphoma

Published on: March 30, 2018

Multicentric lymphoma involving large granular lymphocytes in a cow

S Saari1, A K Järvinen

  • 1Department of Pathological Anatomy, College of Veterinary Medicine, Helsinki, Finland.

Zentralblatt Fur Veterinarmedizin. Reihe A
|December 1, 1994
PubMed

Insights

This case report details the first documented instance of bovine multicentric lymphoma caused by large granular lymphocytes (LGL). The study highlights the presence of these malignant LGLs in various organs of an affected cow.

Area of Science:

  • Veterinary Pathology
  • Oncology
  • Hematology

Background:

  • Multicentric lymphoma is a common malignancy in cattle.
  • Large granular lymphocytes (LGLs) are a distinct lymphocyte subset.
  • Previous literature lacks descriptions of bovine lymphoma involving LGLs.

Observation:

  • A cow presented with nonspecific clinical signs consistent with multicentric lymphoma.
  • Cytological examination of blood and lymph nodes revealed a predominance of LGL-morphology lymphocytes.
  • Histopathological analysis confirmed the presence of malignant LGLs in multiple organs.

Findings:

  • This is the first reported case of bovine multicentric lymphoma characterized by large granular lymphocytes (LGLs).
  • Malignant LGLs infiltrated the liver, kidneys, and lungs.
  • Specific staining techniques (May-Grünwald-Giemsa, hematoxylin-eosin, phosphotungstic acid hematoxylin) highlighted the characteristic granules of the LGLs.

Implications:

  • This finding expands the understanding of lymphoid neoplasms in cattle.
  • It highlights the importance of recognizing LGL morphology in bovine hematopathology.
  • Further research may elucidate the specific pathogenesis and clinical behavior of LGL lymphoma in cattle.

More Related Videos

Collection and Processing of Lymph Nodes from Large Animals for RNA Analysis: Preparing for Lymph Node Transcriptomic Studies of Large Animal Species12:53

Collection and Processing of Lymph Nodes from Large Animals for RNA Analysis: Preparing for Lymph Node Transcriptomic Studies of Large Animal Species

Published on: May 19, 2018

Bovine Mammary Gland Biopsy Techniques14:53

Bovine Mammary Gland Biopsy Techniques

Published on: December 23, 2018

Related Concept Videos

Lymphoid Cells and Tissues01:18

Lymphoid Cells and Tissues

Lymphoid cells and tissues are integral to the immune system, which is crucial in maintaining our body's defense against harmful pathogens. They form the building blocks of lymphoid organs, which include the spleen, thymus, and lymph nodes.
Lymphoid cells consist of various types of immune system cells. These include B and T lymphocytes, which are responsible for producing antibodies and killing infected cells, respectively. Dendritic cells act as messengers between the innate and adaptive...
Primary Lymphoid Organs01:16

Primary Lymphoid Organs

Primary lymphoid organs are pivotal in the formation, development, and maturation of lymphocytes, the white blood cells that serve as the backbone of our immune system. This crucial function underscores their fundamental role in maintaining our overall health and immunity. The two primary lymphoid organs of prime importance are the red bone marrow and the thymus.
The red bone marrow is a soft, spongy tissue nestled in the interior of long bones such as the humerus and femur. It is the site...
Secondary Lymphoid Organs01:15

Secondary Lymphoid Organs

Secondary organs, including lymph nodes, the spleen, and mucosa-associated lymphoid tissue (MALT), work harmoniously to protect us from disease and infection.
The spleen is a vital organ in the lymphatic system, nestled in the upper left side of the abdomen. It is composed of two primary regions: the red pulp and the white pulp, each having distinct functions. The red pulp performs a significant role in blood filtration. It efficiently purges the blood of old or damaged red blood cells and...