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Generation of Human CD40-activated B cells
13:27

Generation of Human CD40-activated B cells

Published on: October 17, 2009

Chromosomal localization of the gene for human B-cell antigen CD40

N Ramesh1, V Ramesh, J F Gusella

  • 1Division of Immunology, Children's Hospital, Boston, Massachusetts.

Somatic Cell and Molecular Genetics
|May 1, 1993
PubMed

Insights

CD40, a key protein in B-cell function, has been mapped to chromosome 20. This finding aids in understanding B-cell development and related immune responses.

Area of Science:

  • Immunology
  • Human Genetics

Background:

  • CD40 is a crucial surface glycoprotein on human B lymphocytes, regulating B-cell development, growth, and differentiation.
  • Anti-CD40 monoclonal antibodies, in conjunction with IL-4, induce isotype switching in B cells.
  • CD40 belongs to a protein family including nerve growth factor receptor, TNF receptor, and Fas.

Purpose of the Study:

  • To determine the chromosomal location of the CD40 gene.
  • To further characterize the CD40 gene and its role in human genetics.

Main Methods:

  • Utilized a panel of human-rodent somatic cell hybrids.
  • Performed gene mapping studies to pinpoint the CD40 locus.

Main Results:

  • The CD40 gene was successfully mapped to human chromosome 20.
  • This mapping provides a precise location for the CD40 gene.

Conclusions:

  • CD40 is located on human chromosome 20.
  • This genetic localization is vital for future research into B-cell biology and immune system disorders.

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