Related Experiment Video
Updated: Aug 18, 2026
Protocol for Long Duration Whole Body Hyperthermia in Mice
Published on: August 25, 2012
[The effect of hyperthermia (45 C) on lymphoid cell aggregation]
Insights
Mild hyperthermia (45°C) impacts immune cell aggregation. It reduces aggregation induced by certain molecules while increasing it with others, likely due to changes in cell surface properties.
Area of Science:
- Immunology
- Cell Biology
- Biophysics
Context:
- Investigating the effects of hyperthermia on immune cell function.
- Understanding cellular responses to thermal stress.
Purpose:
- To determine how mild hyperthermia (45°C) affects rat thymocyte and splenocyte aggregation.
- To explore the mechanisms behind hyperthermia-induced changes in cell aggregation.
Summary:
- Mild hyperthermia (45°C) significantly alters immune cell aggregation patterns.
- Aggregation induced by lectins and sulphated polysaccharides decreased under hyperthermia.
- Aggregation induced by alcian blue increased, suggesting altered cell surface charge and glycoprotein shedding.
Impact:
- Provides insights into the immunomodulatory effects of hyperthermia.
- Suggests potential therapeutic applications of hyperthermia in modulating immune responses.
- Highlights the role of cell surface dynamics in hyperthermia-induced cellular changes.
Abstract:
Hyperthermia (45 degrees C) has found to decrease the rate of rat thymocytes as well as splenocytes aggregation induced by lectins (concanavalin A, wheat germ agglutinin) and sulphated polysaccharides (heparin, dextran sulphate-500) and to increase those induced by cationic dye alcian blue. Shedding of plasma membrane glycoproteins and changes of surface charge are supposed to affect the aggregation.
