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Epithelioid cell histiocytoma. A report of 10 cases including a new cellular variant

E J Glusac1, R J Barr, M A Everett

  • 1Department of Dermatology, University of California, Irvine.

The American Journal of Surgical Pathology
|June 1, 1994
PubMed

Insights

Epithelioid cell histiocytoma, a variant of dermatofibroma, presents with distinct features. This study details ten cases, highlighting variations in presentation and cellularity.

Area of Science:

  • Dermatopathology
  • Histopathology
  • Oncology

Background:

  • Epithelioid cell histiocytoma is a recognized variant of cutaneous fibrous histiocytoma (dermatofibroma).
  • Understanding its diverse presentations is crucial for accurate diagnosis.

Purpose of the Study:

  • To present ten cases of epithelioid cell histiocytoma.
  • To analyze their light microscopic, immunohistochemical, and ultrastructural features.
  • To identify variations in presentation and cellular characteristics.

Main Methods:

  • Case series analysis.
  • Light microscopy examination.
  • Immunohistochemical staining (including Factor XIIIa).
  • Ultrastructural analysis.

Main Results:

  • Eight cases resembled previously reported epithelioid cell histiocytomas, appearing as elevated nodules on extremities with epidermal effacement.
  • Two cases exhibited similar morphology and immunohistochemistry (Factor XIIIa positive) but arose in the reticular dermis with increased cellularity.

Conclusions:

  • Epithelioid cell histiocytoma shows variability in clinical and histological presentation.
  • Factor XIIIa positivity is a key feature.
  • Recognition of these variants aids in differential diagnosis of cutaneous lesions.

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