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Increased levels of circulating intercellular adhesion molecule-1 in patients with localized scleroderma

H Ihn1, M Fujimoto, S Sato

  • 1Department of Dermatology, Faculty of Medicine, University of Tokyo, Japan.

Journal of the American Academy of Dermatology
|October 1, 1994
PubMed

Insights

Serum levels of circulating intercellular adhesion molecule-1 (cICAM-1) were elevated in patients with localized scleroderma. Higher cICAM-1 levels correlated with disease severity and immune markers, suggesting immune activation in localized scleroderma.

Area of Science:

  • Immunology
  • Dermatology
  • Rheumatology

Background:

  • Intercellular adhesion molecule-1 (ICAM-1) plays a role in immune responses.
  • Circulating ICAM-1 (cICAM-1) may indicate immune activation.
  • Localized scleroderma exhibits immunologic abnormalities.

Purpose of the Study:

  • To determine if serum cICAM-1 levels are elevated in localized scleroderma patients.
  • To investigate correlations between cICAM-1 levels and clinical/serologic features of localized scleroderma.

Main Methods:

  • Enzyme-linked immunosorbent assay (ELISA) was used to measure serum cICAM-1.
  • Study included 48 patients with localized scleroderma, 20 with systemic sclerosis, and 20 healthy controls.

Main Results:

  • Serum cICAM-1 levels were significantly higher in localized scleroderma patients compared to controls.
  • Elevated cICAM-1 correlated with lesion count, affected areas, antihistone antibody IgM, and soluble interleukin 2 receptor.

Conclusions:

  • Immune activation appears to be a contributing factor in localized scleroderma.
  • cICAM-1 may serve as a biomarker for immune activity in localized scleroderma.
Abstract

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