Soluble serum interleukin-2 receptor, interleukin-6 and interleukin-1a in patients with endometriosis and in controls
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Updated: Aug 8, 2026
Mouse Model of Surgically-induced Endometriosis by Auto-transplantation of Uterine Tissue
Published on: January 6, 2012
E Koumantakis1, I Matalliotakis, M Neonaki
1Department of Obstetrics and Gynecology, University Hospital, Iraklion, Crete, Greece.
Insights
This study shows that endometriosis elevates interleukin levels, impacting cell-mediated immunity. Danazol treatment significantly reduces these elevated levels, mitigating autoimmune abnormalities associated with endometriosis.
Area of Science:
- Immunology
- Reproductive Endocrinology
Background:
- Endometriosis is associated with altered cell-mediated immunity.
- Elevated interleukin levels, including soluble IL-2 receptor (sIL-2R), IL-6, and IL-1a, are implicated in endometriosis pathogenesis.
Purpose of the Study:
- To investigate the impact of danazol on cell-mediated immunity in women with endometriosis.
- To assess changes in serum sIL-2R, IL-6, and IL-1a levels following danazol treatment.
Main Methods:
- A comparative study involving 10 infertile patients with endometriosis and 10 normal controls.
- Measurement of serum sIL-2R, IL-6, and IL-1a levels before, during, and after a 6-month danazol treatment course in endometriosis patients.
- Single measurement in control group.
Main Results:
- Women with endometriosis exhibited higher baseline levels of sIL-2R, IL-6, and IL-1a compared to controls.
- Danazol treatment led to significant reductions in sIL-2R (P < 0.001), IL-6 (P < 0.05), and IL-1a (P < 0.01) levels.
Conclusions:
- Endometriosis is characterized by increased interleukin levels, suggesting an autoimmune component.
- Danazol effectively reduces elevated interleukin levels and associated autoimmune abnormalities in endometriosis patients.
Abstract:
The aim of this study was to verify to what extent danazol alters cell-mediated immunity. To this end, cell-mediated immunity was studied in 10 infertile patients with endometriosis and in 10 normal controls. Nonspecific parameters studied included serum SIL-2R, IL-6 and IL-1a levels. We also investigated the effect of treatment with Danazol on the levels of SIL-2R, IL-6 and IL-1a in women with endometriosis. Blood SIL-2R, IL-6 and IL-1a levels were measured in endometriotic women before treatment, during the last fifteen days of a 6-months course of Danazol and three months after treatment. Only one blood sample was taken from 10 women without endometriosis. SIL-2R, IL-6 and IL-1a levels were higher in women with endometriosis before treatment compared with controls. Administration of the drug significantly reduced the levels of SIL-2R (P < 0.001), IL-6 (P < 0.05) and IL-1a (P < 0.01). Our findings suggest that endometriosis is a condition which induces a rise in interleukin levels. Danazol also appears significantly to reduce endometriosis-associated autoimmune abnormalities.
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