Related Experiment Video
Updated: Aug 8, 2026

High-throughput Quantitative Real-time RT-PCR Assay for Determining Expression Profiles of Types I and III Interferon Subtypes
Published on: March 24, 2015
[Interferon and blood tumor necrosis factor in 95 patients with HIV infection]
J Constans1, J L Pellegrin, I Pellegrin
1Service de médecine interne et pathologie vasculaire, hôpital Saint-André, Bordeaux.
Insights
Tumor necrosis factor-alpha (TNF-alpha) was elevated in HIV patients and linked to lower CD4 counts. Interferon-alpha correlated with wasting syndrome and abnormal lipid levels in these patients.
Area of Science:
- Immunology
- Virology
- Biochemistry
Abstract:
We have measured TNF-alpha and interferon alpha in 95 HIV positive patients and 20 healthy subjects. TNF-alpha was higher in the HIV+ patients (P = 0.0001) and was correlated to the CD4 cell count (P = 0.02) and cholesterol (negatively) (P = 0.04). Interferon-alpha was correlated to the wasting syndrome (P = 0.002), hypertriglyceridemia (P = 0.004) and haematocrit (P = 0.04).
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