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CD8+ polylobated T-cell leukemia/lymphoma. A case report with immunophenotypic, ultrastructural, gene rearrangement,
H D Friedman1, R E Hutchison, J R Smith
1Department of Pathology and Laboratory Medicine, Syracuse, NY 13210.
Insights
This study details a rare case of polylobated lymphoma in a man with a history of T-cell lymphoma. The research highlights its unique cellular characteristics and genetic profile.
Area of Science:
- Hematology
- Oncology
- Immunology
Background:
- Polylobated lymphoma is a rare morphologic variant of malignant lymphoma.
- It is characterized by neoplastic cells with polylobated nuclei.
Observation:
- An unusual case involved a 57-year-old man with a 9-year history of low-grade peripheral T-cell lymphoma.
- The lymphoma exhibited specific surface antigen expression (CD2, 8, 45, DR) and a clonally rearranged T-cell receptor beta-chain gene.
Findings:
- DNA content analysis revealed diploid and tetraploid populations with a high S phase.
- Cytogenetic analysis identified an abnormal karyotype (45, X, -Y, -1, -10, -10, -17, -19, +5 mar).
- No evidence of retroviral infection (HIV, HTLV) was found.
Implications:
- This case expands the understanding of polylobated T-cell lymphoma presentation and behavior.
- It underscores the importance of detailed immunophenotypic and genotypic analysis in diagnosing rare lymphoma subtypes.
- Further research into the pathogenesis and treatment of polylobated lymphoma is warranted.
Abstract:
Polylobated lymphoma is a morphologic variant of malignant lymphoma characterized by large pleomorphic neoplastic cells with polylobated nuclei. We report an unusual case in a 57-year-old man with a 9-year history of an antecedent low-grade peripheral T-cell lymphoma with dermal involvement. The polylobated lymphoma expressed the CD2, 8, 45, and DR surface antigens and had a clonally rearranged T-cell receptor beta-chain gene. The DNA content analysis indicated that most of the neoplasm was DNA diploid and tetraploid, with a high S phase. Cytogenetic analysis demonstrated the presence of a clone with an abnormal karyotype 45, X, -Y, -1, -10, -10, -17, -19, +5 mar. Serology and polymerase chain reaction analysis showed no evidence of retroviral infection (human immunodeficiency virus types 1 and 2 and human T-cell lymphotropic virus types I and II). We review the literature on polylobated T-cell lymphoma.
