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Published on: March 25, 2016
[Pathologic and immunohistochemical study of non-Hodgkin's lymphoma]
1Department of Pathology, Norman Bethune University of Medical Sciences, Jilin.
Insights
This study analyzed 114 non-Hodgkin's lymphoma (NHL) cases in Changchun. B-cell lymphomas were most common, with diffuse large non-cleaved cell type being the most frequent subtype.
Area of Science:
- Hematology
- Oncology
- Immunohistochemistry
Context:
- Non-Hodgkin's lymphoma (NHL) is a heterogeneous group of lymphoid malignancies.
- Understanding the epidemiological and pathological characteristics of NHL is crucial for diagnosis and treatment.
Purpose:
- To classify and analyze the clinicopathological features of 114 non-Hodgkin's lymphoma (NHL) cases using immunohistochemistry.
- To provide insights into the distribution of NHL subtypes, primary sites, grades, and demographic factors in the Changchun population.
Summary:
- Immunohistochemical analysis of 114 non-Hodgkin's lymphoma (NHL) cases revealed B-cell lymphomas in 81.6% and T-cell lymphomas in 18.4%.
- The diffuse large non-cleaved cell type was the most prevalent B-cell subtype (38.6%).
- Nodal primary sites accounted for 54.4%, with cervical nodes being most common, while extranodal sites (45.6%) were frequently observed in the intestine and stomach.
- Intermediate grade lymphomas constituted the largest proportion (71.9%).
- The age distribution was bimodal, peaking in the 20-29 and 40-59 year age groups, with a mean age of 39.3 years and a male to female ratio of 2.9:1.
Impact:
- This study contributes to the understanding of NHL epidemiology in a specific Chinese population.
- Findings can aid in refining diagnostic criteria and developing targeted therapeutic strategies for NHL subtypes.
- The detailed clinicopathological data can inform future research and clinical management of non-Hodgkin's lymphoma.
Unlabelled:
114 cases of non-Hodgkin's lymphoma (NHL) encountered in Changchun were studied by immunohistochemistry and classified according to the Working Formulation (WF).
Results:
B cell type 93 cases (81.6%), of which the largest number being the diffuse large non cleaved type (44 cases, 38.6%) and the smallest number being the small lymphocytic type (3 cases, 2.6%). T cell type 21 cases (18.4%), of which 10 cases were of the lymphoblastic type. 54.4% of the primary sites being nodal, with cervical nodes having the highest incidence followed by mesenteric nodes and posterior peritoneal nodes. The remainder, 45.6%, being extranodal, the intestine was the most frequent site followed by the stomach. Malignant grade, intermediate grade formed the largest group (71.9%), high grade the next largest (18.4%) and low grade the smallest (9.7%). Age distribution was bimodal, with the highest peak in the age group of 20-29 years, the second peak in the age-group of 40-59 years, and the overall mean age was 39.3 years. Male to female ratio was 2.9:1.
