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Published on: May 21, 2014
[Immunohistochemical identification of secretory component (SC) in activated mesothelial cells]
F Morea1, M Albrizio, A L'Abbate
1U.S.L. BA 18, Putignano, Bari.
Insights
Mesothelial cells synthesize Secretory Component (SC) but do not show intracellular IgA. This suggests SC may have roles beyond IgA transport in glandular epithelial specialization.
Area of Science:
- Immunohistochemistry
- Cell Biology
- Gastroenterology
Context:
- Mesothelial cells line serous cavities.
- Secretory Component (SC) is crucial for transporting Immunoglobulin A (IgA) antibodies.
- The role of SC in mesothelial cells is not fully understood.
Purpose:
- To investigate the presence of Secretory Component (SC) synthesis and IgA antibody transport in activated mesothelial cells.
- To determine if mesothelial cells actively transport IgA.
Summary:
- Immunohistochemical analysis of 22 cytoblocks from serous effusions revealed SC synthesis in mesothelial cells.
- Intracytoplasmic IgA was not detected, indicating mesothelial cells may not transport IgA in the same manner as other epithelial cells.
- This suggests SC may have functions independent of IgA transport in mesothelial cells.
Impact:
- Challenges the established understanding of SC function.
- Suggests novel, potentially unknown roles for SC in glandular epithelial specialization.
- Opens new avenues for research into mesothelial cell biology and epithelial transport mechanisms.
Abstract:
Twenty-two cytoblocks from serous effusions very rich in activated mesothelial cells were immunohistochemically tested to indicate about the presence of synthesis of Secretory Component and transport of IgA Antibodies across mesothelium; the tests were positive for S.C., while failed in order to demonstrate intracytoplasmic IgA. Authors hypothesize that association between Secretory Component synthesis and IgA transport may be not necessary absolute and that Secretory Component may play another unknown role related to glandular epithelial specialisation.
