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[The immunological indices of patients with echinococcosis undergoing preoperative hemoexfusions]
Insights
Hemopurification (HE) impacts immunologic parameters in hydatid disease patients. Parameters temporarily change post-HE but return to baseline within days, necessitating individualized patient screening for preoperative HE.
Area of Science:
- Immunology
- Parasitology
- Hepatology
Background:
- Hydatid disease, caused by Echinococcus granulosus, affects the liver and abdomen.
- Immunologic status is crucial for managing hydatid disease, especially with complications like suppuration.
- Hemopurification (HE) is a potential preoperative intervention for these patients.
Purpose of the Study:
- To investigate the immunologic parameter changes in hydatid disease patients before and after hemopurification (HE).
- To compare these changes across different clinical presentations of hydatid disease.
Main Methods:
- Studied 38 patients with liver and abdominal hydatid disease.
- Assessed immunologic parameters before and after a single 400 ml hemopurification (HE).
- Compared patients with uncomplicated disease, suppuration, and complicated suppuration/calcification to controls.
Main Results:
- Immunologic parameters differed between patient groups and controls in the first 24 hours post-HE.
- Parameters in both patient groups returned to baseline levels 3-5 days after HE.
- Significant variations observed based on disease complexity and suppuration.
Conclusions:
- Hemopurification causes transient immunologic alterations in hydatid disease patients.
- Individualized patient assessment, considering clinical form and complications, is vital for preoperative HE screening.
- Further research may clarify the long-term immunologic impact and optimal use of HE.
Abstract:
The immunologic parameters were studied in 38 patients with hydatid disease of the liver and abdomen before and after a single hemoexfusion (HE) in a volume of 400 ml. Among the patients who were examined there were those with uncomplicated hydatid disease of the liver (group I, second clinical stage, 25 persons), patients with suppuration of hydatid cysts (group 11, 10 persons), and two patients with multiple hydatid cysts complicated by their suppuration and calcification with involvement of large areas of the liver. Comparative analysis of immunological parameters in patients before and in the first 24 hours after HE showed a difference between the groups of patients and the controls. The parameters were restored to their initial values in patients of both groups 3-5 days after HE. The results of the study allow the conclusion that in screening patients with hydatid disease of the liver and abdominal cavity for preoperative HE a strict individual approach is necessary with the patient's general condition, the clinical form of the disease, and complications on the part of the cysts being taken into account.
