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Lactic dehydrogenase anomaly in a patient with chronic renal failure
T Shibasaki1, Y Kaguchi, I Ohno
1Second Department of Internal Medicine, Jikei University School of Medicine, Tokyo, Japan.
Insights
A rare lactic dehydrogenase (LDH)-immunoglobulin A (IgA) complex, or LDH anomaly, was found in a patient with chronic renal failure (CRF). This finding in serum and pleural effusion requires further investigation for clinical significance.
Area of Science:
- Nephrology
- Clinical Chemistry
- Immunology
Background:
- Chronic renal failure (CRF) patients often present with complex clinical manifestations.
- Diagnostic challenges can arise from unusual biochemical findings in patients with end-stage renal disease.
Observation:
- A 67-year-old male undergoing maintenance dialysis for CRF was diagnosed with a right-sided pleural effusion.
- Electrophoresis revealed a lactic dehydrogenase (LDH)-immunoglobulin A (IgA) complex in both serum and pleural fluid.
Findings:
- The detected complex was identified as an IgA (kappa light chain) immunoglobulin.
- This specific LDH anomaly is exceptionally uncommon in individuals with CRF.
Implications:
- The clinical significance of LDH-IgA complexes in CRF patients with pleural effusion is currently unknown.
- Further research is warranted to elucidate the role and impact of this rare finding in renal failure patients.
Abstract:
A 67-year-old man with chronic renal failure (CRF) was defined to have lactic dehydrogenase (LDH)-immunoglobulin A (IgA) complex, the so-called "LDH anomaly", in his serum and pleural effusion. He was found to have a pleural effusion on the right side during maintenance dialysis at a satellite hospital. A LDH-IgA complex was detected in the serum and pleural effusion by the method of current electrophoresis. The immunoglobulin class was found to be IgA (K) by counter immunoelectrophoresis. LDH anomaly is extremely rare in patients with CRF; the clinical significance of this substance in serum and pleural effusion remains unclarified.