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Ki-1-positive large cell anaplastic lymphoma diagnosed by urinary cytology. A case report
Insights
Urinary cytology identified Ki-1-positive large cell anaplastic lymphoma cells in a patient. Immunocytochemistry confirmed tumor cells expressed the Ki-1 antigen and activation markers.
Area of Science:
- Oncology
- Cytopathology
- Immunology
Background:
- Large cell anaplastic lymphoma (LCAL) is a distinct lymphoma subtype.
- Ki-1 (CD30) antigen expression is a hallmark of LCAL.
- Urinary cytology is typically used for detecting urothelial abnormalities.
Abstract:
Cytomorphologic and immunocytochemical findings in urinary cytology in a case of Ki-1-positive large cell anaplastic lymphoma in the left cervical region in a 42-year-old man are reported. Smears stained with Papanicolaou or Wright-Giemsa stain showed a cytomorphologic spectrum that varied from immunoblastlike cells to large neoplastic cells with pleomorphic nuclei and vacuolated cytoplasm. Neoplastic cells with multilobulated, bizarre nuclei and mitosis were also observed. Immunocytochemistry on urinary sediments showed that the tumor cells were of a "null" phenotype and strongly expressed the Ki-1 antigen and "activation" markers of HLA-DR, Tac (CD25) and OKT9 (CD71). Histology and immunohistochemistry confirmed these findings.
