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[CD23: structures, functions and practical perspectives in allergy reactions]

A Lachaux1, D Kaiserlian

  • 1Département de pédiatrie, pavillon S, hôpital E-Herriot, Lyon, France.

Pediatrie
|January 1, 1993
PubMed

Insights

CD23, a receptor for IgE, is found on immune cells and can be cleaved into soluble fragments. Elevated soluble CD23 levels are common in allergic patients, suggesting its role in allergy.

Area of Science:

  • Immunology
  • Molecular Biology

Context:

  • CD23 is the low-affinity receptor for IgE.
  • It functions as a surface cell marker expressed on B and T lymphocytes, and other cells like tumor cells.
  • Soluble CD23 (sCD23) is generated through autocatalytic cleavage of surface CD23.

Purpose:

  • To detail the structural characteristics and functional roles of CD23.
  • To explore the regulation of CD23 expression.
  • To investigate the clinical relevance of sCD23 in allergic conditions.

Summary:

  • CD23, a key receptor for IgE, is expressed on various immune cells and tumor cells.
  • Its expression is significantly induced by Interleukin-4 (IL4) and IgE.
  • CD23 mediates crucial functions including B cell growth, differentiation, antigen presentation, and inflammation.
  • The study highlights the cleavage of surface CD23 into soluble fragments and notes increased serum sCD23 levels in allergic patients.

Impact:

  • Provides insights into the multifaceted roles of CD23 in immune responses and cellular processes.
  • Establishes a link between elevated sCD23 levels and allergic diseases.
  • Offers potential for CD23 as a biomarker for allergy diagnosis and management.

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