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Published on: January 9, 2019
Novel eosinophilic intracytoplasmic inclusions in a meningioma
K Kawasaki1, H Takahashi, H Kaneko
1Department of Pathology, Niigata University, Japan.
Insights
Researchers identified unique eosinophilic intracytoplasmic inclusions in a meningothelial meningioma case. These novel inclusions have distinct ultrastructural features, with their molecular basis remaining unclear.
Area of Science:
- Neuropathology
- Cell Biology
Background:
- Meningiomas can exhibit extracellular or intracytoplasmic inclusions.
- A rare case of meningothelial meningioma presented with unusual round eosinophilic intracytoplasmic inclusions.
Observation:
- Ultrastructural analysis revealed inclusions within tumor cell cytoplasm and processes.
- Inclusions featured a central filamentous core with radiating peripheral filaments, intermingled with crystalloid lamellar structures and granules.
- No surrounding membrane was detected.
Findings:
- Immunohistochemical studies showed no reactivity for intermediate filaments, actin, ubiquitin, or amyloid.
- The observed inclusions possess ultrastructural characteristics distinct from previously documented types.
Implications:
- These findings expand the understanding of cellular variations in meningiomas.
- Further research is needed to elucidate the molecular composition and origin of these novel inclusions.
Background:
Two forms of inclusion, extracellular and intracytoplasmic, have been reported in meningiomas. The authors recently encountered a case of meningothelial meningioma with unusual round eosinophilic intracytoplasmic inclusions.
Methods:
Ultrastructural and immunohistochemical studies were performed on the surgically removed tissue.
Results:
Ultrastructurally, the inclusions were found in the cytoplasm and processes of the tumor cells. Each inclusion consisted of a dense central mass of filaments with a looser, less dense periphery of radiating filaments. At the periphery, crystalloid lamellar structures and granules were intermingled frequently. No limiting membrane was observed. Immunohistochemically, the inclusions were unreactive for five classes of intermediate filaments, actin, ubiquitin, and amyloid.
Conclusion:
The intracytoplasmic inclusions were ultrastructurally distinct from those reported previously. The molecular aspect of these novel eosinophilic intracytoplasmic inclusions remained uncertain.
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