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Iodixanol in femoral arteriography (phase III): a comparative double-blind parallel trial between iodixanol and

N D Pugh1, G R Sissons, M S Ruttley

  • 1Department of Medical Physics, University Hospital of Wales, Cardiff, UK.

Clinical Radiology
|February 1, 1993
PubMed

Insights

This study compared iodixanol and iopromide, two contrast media (CM), in aortofemoral arteriography. Both were safe and effective, with iodixanol causing less warmth sensation and a smaller increase in femoral blood flow.

Area of Science:

  • Radiology
  • Vascular Imaging
  • Contrast Media Research

Background:

  • Iodixanol is a non-ionic, dimeric contrast medium (CM) designed to be isotonic with blood.
  • Iopromide is another commonly used non-ionic CM.

Purpose of the Study:

  • To compare the safety and efficacy of iodixanol versus iopromide in aortofemoral arteriography.
  • To evaluate radiographic quality, patient discomfort, adverse events, femoral blood flow, and renal function.

Main Methods:

  • A parallel, double-blind study involving 100 patients undergoing peripheral arteriography.
  • Patients were randomly assigned to receive either iodixanol or iopromide.
  • Assessment included radiographic quality, adverse events, patient-reported warmth sensation, femoral blood flow measurements, and renal function markers.

Main Results:

  • Radiographic quality was similar between iodixanol and iopromide.
  • Adverse events were mild and transient, with no significant difference between groups (6% iodixanol vs. 11% iopromide).
  • Iodixanol resulted in a significantly milder sensation of warmth and a smaller increase in femoral blood flow compared to iopromide. Renal function was minimally affected by both, with differing impacts on specific markers.

Conclusions:

  • Both iodixanol and iopromide are safe, effective, and well-tolerated contrast media for aortofemoral arteriography.
  • The primary difference lies in their hemodynamic effects, with iodixanol showing a lesser impact on femoral blood flow and patient-reported warmth.

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