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[Central effects of iohexol and iopamidol, non-ionic contrast media]

K Kisara1, S Sakurada, T Tadano

  • 1Department of Pharmacology, Tohoku College of Pharmacy, Sendai, Japan.

Nihon Yakurigaku Zasshi. Folia Pharmacologica Japonica
|April 1, 1993
PubMed

Insights

Iohexol and iopamidol, commonly used contrast agents, showed distinct central nervous system effects in mice, including hypothermia and altered activity, suggesting varied pharmacological actions despite similar LD50 values.

Area of Science:

  • Pharmacology
  • Neuroscience
  • Toxicology

Background:

  • Iohexol and iopamidol are widely used iodinated contrast media.
  • Their central nervous system (CNS) effects require thorough investigation.

Purpose of the Study:

  • To compare the central nervous system effects of intravenously administered iohexol and iopamidol in mice.
  • To evaluate potential differences in their pharmacological actions.

Main Methods:

  • Comparative study using iohexol, iopamidol, and mannitol as a reference in ddY and ICR mice.
  • Assessment of neurological and physiological parameters including startle response, locomotor activity, narcosis potentiation, hypothermia, mortality under electric stimulus, and tests for anticonvulsant, electroencephalic, muscle relaxant, and antinociceptive activities.

Main Results:

  • No significant differences in startle response compared to mannitol.
  • Iopamidol inhibited locomotor activity; iohexol potentiated thiopental-induced narcosis.
  • High doses of both agents caused hypothermia and increased mortality with electric stimulus.
  • No notable CNS activities were observed in anticonvulsant, electroencephalic, muscle relaxant, or antinociceptive tests.

Conclusions:

  • Iohexol and iopamidol do not exhibit identical pharmacological profiles on the central nervous system.
  • Despite high LD50 values (approx. 15000 mgI/kg), specific CNS effects warrant consideration.
  • Further research may be needed to fully elucidate their neuropharmacological properties.

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