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[Changes in plasma cytokine levels during lung surgery]
T Taniguchi1, Y Matsumoto, T Yoneda
1Department of Anesthesiology and Intensive Care Medicine, School of Medicine, Kanazawa University.
Insights
Plasma cytokine levels, including interleukin-6 (IL-6) and interleukin-8 (IL-8), rise during lung surgery. These changes correlate with surgical stress but not severe postoperative complications in this study.
Area of Science:
- Immunology
- Surgical Oncology
Context:
- Lung surgery involves significant physiological stress.
- Cytokines play a crucial role in the inflammatory response to surgical trauma.
Purpose:
- To investigate the dynamic changes in plasma interleukin-6 (IL-6) and interleukin-8 (IL-8) levels during lung surgery.
- To correlate these cytokine level changes with the degree of surgical stress and postoperative complications.
Summary:
- Plasma levels of IL-6 and IL-8 were monitored in 20 patients undergoing lung surgery.
- A significant increase in IL-6 and IL-8 was observed shortly after surgical incision, peaking at the end of surgery.
- Cytokine level alterations correlated with surgical duration, blood loss, and C-reactive protein (CRP) levels for two days post-surgery.
Impact:
- This study highlights the rapid inflammatory response to surgical procedures.
- Understanding cytokine dynamics can help in assessing surgical stress and potentially predicting patient outcomes.
- No severe postoperative complications were noted, suggesting effective perioperative management despite inflammatory markers.
Abstract:
We studied the changes in plasma cytokine (IL-6 and IL-8) levels during lung surgery in 20 patients. The correlation between the changes in cytokine levels and surgical stress as well as the postoperative complications were examined. The levels of IL-6 and IL-8 increased shortly after the surgical incision and were 326 pg.ml-1 and 61 pg.ml-1 respectively, at the end of surgery. The changes in cytokine levels correlated well with the duration of surgery, blood loss and CPR levels for 2 days after the surgery. However, there were no severe postoperative complications in the present study. We conclude that the cytokines increase shortly after the surgical incision and the changes in cytokine levels correlate well with the surgical stress.