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Plasmacytoid CD8 lymphoma: morphologic and immunologic characterization
L Amiot1, P Tas, S Caulet-Maugendre
1Laboratoire d'Hématologie-Immunologie, CHRU, Rennes, France.
Insights
This study details a rare T-cell lymphoma presenting with plasmacytoid features. Immunophenotypic analysis confirmed abnormal T-cell proliferation, crucial for diagnosing this lymphoma.
Area of Science:
- Hematology
- Immunology
- Oncology
Background:
- Lymphadenopathy and fever are common symptoms requiring differential diagnosis.
- Plasmacytoid morphology in lymph node biopsies can present diagnostic challenges.
Observation:
- A 79-year-old female presented with fever and lymphadenopathy.
- Lymph node biopsy revealed diffuse infiltration by medium-sized cells with plasmacytoid features.
Findings:
- Immunophenotyping demonstrated suppressor T-cell antigen (CD2, CD3, CD7, CD8) expression.
- Absence of CD5 expression and clonal T-cell receptor gamma gene rearrangement confirmed abnormal T-cell proliferation.
- Immunoglobulin heavy-chain gene rearrangement was absent, ruling out B-cell lineage.
Implications:
- Accurate immunophenotypic analysis is essential for diagnosing T-cell lymphomas with unusual morphology.
- This case highlights the importance of immunological studies in differentiating T-cell lymphomas from B-cell neoplasms.
- Understanding aberrant T-cell antigen expression aids in classifying rare hematologic malignancies.
Abstract:
This study describes a 79 year-old female suffering from fever and lymphadenopathy. A lymph node biopsy showed diffuse infiltration of medium-sized cells with plasmacytoid features. The immunologic phenotype determined by cytometric analysis and immunochemistry showed suppressor T antigen (CD2, CD3, CD7, CD8) expression. Absence of CD5 expression characterized this abnormal T cell proliferation. Gamma T cell receptor rearrangement without immunoglobulin heavy-chain gene rearrangement confirmed the T lineage of these plasmacytoid cells and their clonality. Immunological studies are necessary for identification of this T lymphoma with B microscopic findings.