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Invasive malignant fibrous histiocytoma in a cow
E A Sartin1, J A Hudson, G A Herrera
1Department of Pathobiology, College of Veterinary Medicine, Auburn University, AL 36849-5519, USA.
Insights
A rare malignant fibrous histiocytoma was found in a cow, affecting the frontal bone and brain. Trauma and chronic inflammation may increase the risk of such bovine neoplasia.
Area of Science:
- Veterinary Pathology
- Oncology
- Bovine Medicine
Background:
- Malignant fibrous histiocytoma (MFH) is a rare tumor in cattle.
- Invasive tumors can cause significant bone lysis and neurological signs.
Abstract:
An invasive malignant fibrous histiocytoma associated with the left cornual process, and causing lysis of the frontal bone, was diagnosed in a cow. The mass compressed the left cerebral hemisphere focally and extended into the frontal sinus and ethmoid and nasal turbinates. It was composed of pleomorphic to spindle-shaped cells with ultra-structural evidence of fibroblastic, myofibroblastic, and fibrohistiocytic differentiation. Trauma and chronic inflammation may be predisposing factors for development of neoplasia in cattle.