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Circulating soluble intercellular adhesion molecule-1 in type C viral hepatitis

S S Yang1, G Tsai, C H Wu

  • 1Division of Gastroenterology, Cathay General Hospital, Taipei, Taiwan.

Hepato-Gastroenterology
|May 1, 1996
PubMed

Insights

Soluble intercellular adhesion molecule-1 (sICAM-1) levels are elevated in acute and chronic hepatitis C infections. These elevated sICAM-1 levels correlate with liver injury markers, suggesting ICAM-1’s role in hepatocellular damage.

Area of Science:

  • Immunology
  • Hepatology
  • Virology

Background:

  • Intercellular adhesion molecule-1 (ICAM-1) is an immunoglobulin supergene family member.
  • ICAM-1 expression is induced by inflammatory mediators and cellular activation.
  • Soluble ICAM-1 (sICAM-1) serves as a biomarker in various inflammatory conditions.

Purpose of the Study:

  • To investigate circulating soluble ICAM-1 (sICAM-1) levels in patients with acute and chronic hepatitis C virus (HCV) infection.
  • To compare sICAM-1 levels between acute HCV, chronic HCV, and healthy individuals.
  • To explore the correlation between sICAM-1 levels and markers of liver injury in HCV infection.

Main Methods:

  • Enzyme immunoassay method was used to quantify sICAM-1 levels.
  • Blood samples were collected from 10 patients with acute hepatitis C, 25 patients with chronic hepatitis C, and 10 healthy volunteers.
  • Serum aminotransferase (ALT) activities, total bilirubin, and albumin levels were measured.

Main Results:

  • Mean sICAM-1 levels were significantly higher in both acute (1394 +/- 502 ng/ml) and chronic (662 +/- 477 ng/ml) hepatitis C compared to healthy volunteers (339 +/- 93 ng/ml).
  • Acute hepatitis C exhibited higher maximum sICAM-1 activity than chronic hepatitis C (P = 0.009).
  • sICAM-1 levels showed a positive correlation with ALT (P < 0.001) and total bilirubin (P = 0.001), and a negative correlation with albumin (P = 0.01).

Conclusions:

  • ICAM-1 plays a significant role in hepatocellular injury associated with viral hepatitis C infection.
  • Elevated sICAM-1 levels can precede the rise in ALT activity in acute hepatitis C.
  • sICAM-1 is a potential biomarker for assessing liver damage severity in hepatitis C.
Abstract

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