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Perianal cytomegalovirus ulcer in an HIV-infected patient
F Aloi1, C Solaroli, M Papotti
1Department of Dermatology, University of Turin, Italy.
Dermatology (Basel, Switzerland)
|January 1, 1996
Insights
Cytomegalovirus (CMV) caused a perianal ulcer in an immunocompromised patient. Ganciclovir treatment effectively resolved the CMV-related ulcer.
Area of Science:
- Infectious Diseases
- Virology
- Gastroenterology
Background:
- Acquired immunodeficiency syndrome (AIDS) increases susceptibility to opportunistic infections.
- Perianal ulcers can be a manifestation of severe infections in immunocompromised individuals.
Observation:
- A 51-year-old man with AIDS presented with a perianal ulcer.
- Histological examination revealed cytomegalic inclusions in endothelial cells and fibroblasts.
- No Herpes simplex virus cytopathic effects were observed.
Findings:
- Immunohistochemistry and in situ hybridization confirmed Cytomegalovirus (CMV) within infected cells.
- The perianal ulcer was diagnosed as CMV-induced.
Implications:
- This case highlights CMV as a cause of perianal ulcers in AIDS patients.
- Ganciclovir is an effective treatment for CMV-related perianal ulcers in this population.
Abstract:
A 51-year-old man with acquired immunodeficiency syndrome presented with a perianal ulcer. Histologically there were numerous cytomegalic inclusions within endothelial cells and stomal fibroblasts. Cytomegalovirus within infected cells was demonstrated by immunohistochemistry and in situ hybridization. No cytopathic typical of Herpes simplex were detected. The ulcer resolved completely after a treatment with ganciclovir.