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Cadherins in reactive lymph nodes and lymphomas: high expression in anaplastic large cell lymphomas

M Ashton-Key1, G P Cowley, M E Smith

  • 1Department of Histopathology, University College London Medical School, UK.

Histopathology
|January 1, 1996
PubMed

Insights

This study examined cadherin expression in lymphomas using antibodies. Pan-cadherin was found in several lymphoma types, but E-cadherin was absent, suggesting cadherins influence lymphoma cell appearance.

Area of Science:

  • Immunohistochemistry
  • Cell Biology
  • Oncology

Background:

  • Cadherins are crucial cell adhesion molecules involved in tissue structure.
  • Understanding cadherin expression in lymphomas can provide insights into their behavior and morphology.

Purpose of the Study:

  • To investigate the expression patterns of pan-cadherin and E-cadherin in various types of lymphomas and reactive lymph nodes.
  • To correlate cadherin expression with lymphoma subtypes and cellular morphology.

Main Methods:

  • Immunohistochemical staining of routinely processed lymph node tissues using polyclonal pan-cadherin and monoclonal E-cadherin (HECD-1) antibodies.
  • Analysis of 48 lymphomas (T-cell, high-grade B-cell, low-grade B-cell, anaplastic large cell, Hodgkin's disease) and nine reactive lymph nodes.

Main Results:

  • Pan-cadherin staining was observed in reactive lymph node endothelium and granulomas, but not lymphoid cells.
  • Pan-cadherin was detected in T-cell, high-grade B-cell, anaplastic large cell lymphomas, and Hodgkin's disease, but not low-grade B-cell lymphomas.
  • E-cadherin was not detected in any lymphomas exhibiting pan-cadherin expression. Anaplastic large cell lymphomas showed the most frequent and strongest cadherin expression.

Conclusions:

  • Cadherin expression, particularly pan-cadherin, is present in specific lymphoma subtypes.
  • The absence of E-cadherin in pan-cadherin-positive lymphomas suggests distinct roles for different cadherins.
  • The prominent cadherin expression in anaplastic large cell lymphomas may contribute to their epithelioid phenotype and resemblance to carcinoma.

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