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Cerebral venous thrombosis after myelography with iopamidol

H Brugeilles1, I Pénisson-Besnier, A Pasco

  • 1Service de Neurologie A, Hôpital Larrey, Centre Hospitalier et Universitaire d'Angers, France.

Neuroradiology
|August 1, 1996
PubMed

Insights

A patient developed severe brain swelling and blood clots after a myelography procedure using iopamidol contrast dye. This rare complication may be linked to the contrast medium

Area of Science:

  • Neurology
  • Radiology
  • Vascular Medicine

Background:

  • Myelography is an imaging procedure used to visualize the spinal cord.
  • Non-ionic water-soluble contrast media, such as iopamidol, are commonly used in myelography.
  • Intracranial hypertension is a condition characterized by elevated pressure within the skull.

Observation:

  • A young male patient presented with immediate intracranial hypertension post-myelography.
  • Cerebral angiography revealed extensive cerebral venous thrombosis.
  • Common causes of thrombophlebitis were ruled out.

Findings:

  • A potential causal link between iopamidol contrast medium and cerebral venous thrombosis was suspected.
  • A similar case report supports the association.
  • The rheological effects and hemo-concentration induced by iopamidol may precipitate this complication.

Implications:

  • This case highlights a rare but serious adverse event associated with iopamidol.
  • Further investigation into the rheological and hemo-concentrating effects of contrast media is warranted.
  • Clinicians should be vigilant for signs of cerebral venous thrombosis following myelography.

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