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Elimination of ioversol by hemodialysis

J Ueda1, T Furukawa, S Takahashi

  • 1Department of Radiology, Sumitomo Hospital, Osaka, Japan.

Acta Radiologica (Stockholm, Sweden : 1987)
|September 1, 1996
PubMed

Insights

Ioversol contrast media is effectively removed during hemodialysis in patients with chronic renal failure. This study confirms ioversol

Area of Science:

  • Radiology and Nephrology
  • Pharmacokinetics and Contrast Media

Background:

  • Chronic renal failure (CRF) necessitates careful consideration of contrast media administration.
  • Assessing the dialysability of iodinated contrast agents is crucial for patient safety in hemodialysis.

Purpose of the Study:

  • To investigate the dialysability of ioversol in patients undergoing chronic hemodialysis.
  • To evaluate the safety and efficacy of ioversol in patients with impaired kidney function.

Main Methods:

  • 100 ml of ioversol was administered intravenously to 12 CRF patients during CT scans.
  • Hemodialysis was initiated within 30 minutes and continued for 4 hours post-injection.
  • Blood samples were collected at timed intervals to determine ioversol elimination rates and half-life.

Main Results:

  • Mean ioversol dialysance ranged from 114 to 129 ml/min.
  • An elimination rate of 82.5% was achieved within 4 hours of hemodialysis.
  • The mean half-life of ioversol during hemodialysis was 1.80 hours, with only mild heat sensations reported as side effects.

Conclusions:

  • Ioversol is effectively removed from circulation by hemodialysis.
  • No severe adverse reactions were observed, indicating ioversol is suitable for hemodialyzed patients.
Abstract

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