Related Experiment Video

Updated: Aug 8, 2026

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis
07:29

Three Different Protocols of Corneal Collagen Crosslinking in Keratoconus: Conventional, Accelerated and Iontophoresis

Published on: November 12, 2015

[The immunity of patients with keratoconus]

L N Tarasova1, E N Gorskova, S N Teplova

  • 1Department of Ophthalmology of Uralsk Advanced Training Institute for Doctors, Cheliabinsk

Vestnik Oftalmologii
|July 1, 1996
PubMed

Insights

Immune system imbalances were found in keratoconus patients, affecting T-lymphocytes and immunoglobulin levels. These findings suggest compromised immune homeostasis in individuals with this corneal disease.

Area of Science:

  • Immunology
  • Ophthalmology
  • Corneal Diseases

Background:

  • Keratoconus is a progressive thinning of the cornea.
  • Immune system dysregulation may play a role in keratoconus pathogenesis.
  • Understanding immune changes is crucial for managing keratoconus.

Purpose of the Study:

  • To investigate cellular and humoral immunity in patients with keratoconus.
  • To assess immune homeostasis at different stages of the disease.
  • To identify specific immune markers associated with keratoconus.

Main Methods:

  • Studied cellular and humoral immunity parameters.
  • Analyzed T-lymphocytes and their subpopulations.
  • Measured immunoglobulin levels, complement components (C3, C4), and lysozyme activity.
  • Assessed NBT-positive and phagocytic cells.

Main Results:

  • Impaired immune homeostasis observed in keratoconus patients.
  • Shifts in T-lymphocyte populations noted.
  • Dysgammaglobulinemia with elevated primary immune response immunoglobulins.
  • Increased C3 and C4 complement components with reduced total hemolytic activity.
  • Elevated NBT-positive and phagocytic cells, decreased serum lysozyme activity.

Conclusions:

  • Keratoconus is associated with significant alterations in immune parameters.
  • Both local corneal involvement and systemic immune shifts are evident.
  • Immune dysregulation contributes to the pathophysiology of keratoconus.

More Related Videos

A Non-invasive Way to Isolate and Phenotype Cells from the Conjunctiva07:35

A Non-invasive Way to Isolate and Phenotype Cells from the Conjunctiva

Published on: July 5, 2017

Corneal Sensitivity Testing Procedure for Ophthalmologic and Optometric Patients04:00

Corneal Sensitivity Testing Procedure for Ophthalmologic and Optometric Patients

Published on: August 2, 2024

Related Concept Videos

Cell-mediated Immune Responses01:40

Cell-mediated Immune Responses

Overview
Cytotoxic T Cells-mediated Immune Response01:27

Cytotoxic T Cells-mediated Immune Response

Cytotoxic T cells are a vital component of the immune system. They have the remarkable ability to identify and target antigens on infected or abnormal cells. These antigens often originate from intracellular pathogens such as viruses or abnormal proteins cancer cells produce.
Immunological surveillance is the ability of immune cells to monitor and eliminate infected cells with intracellular pathogens, neoplastically transformed cells, and cells with non-self antigens. Cytotoxic T cells and NK...
Microbiome of the Eye01:22

Microbiome of the Eye

The human eye has a specialized microbiota that reflects its unique anatomical and immunological environment. This low-biomass microbial community predominantly colonizes the conjunctiva and eyelid margins, playing a vital role in ocular surface homeostasis and defense. Despite its proximity to the richly colonized facial skin, the ocular surface maintains a distinct microbial profile due to continuous mechanical and biochemical defense mechanisms.The conjunctival surface hosts fewer microbial...