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Case report: primary CD30 (Ki-1)-positive anaplastic large cell lymphoma of the duodenum
I Yoshikawa1, I Murata, Y Tanaka
1Third Department of Internal Medicine, University of Occupational and Environmental Health, Japan, School of Medicine, Kitakyushu.
Insights
This report details the first known case of primary Ki-1 anaplastic large cell lymphoma in the duodenum. The patient achieved complete remission after modified CHOP therapy.
Area of Science:
- Oncology
- Hematology
- Gastrointestinal Oncology
Background:
- Ki-1 anaplastic large cell lymphoma (ALCL) is a recognized subtype of non-Hodgkin's lymphoma.
- Primary gastrointestinal lymphomas are rare, with specific subtypes presenting unique clinical challenges.
Observation:
- A 62-year-old male presented with a rare manifestation of cancer.
- The patient was diagnosed with a primary Ki-1 anaplastic large cell lymphoma located in the duodenum.
Findings:
- The case represents the first documented instance of primary Ki-1 anaplastic large cell lymphoma originating in the duodenum.
- The patient was treated with a modified cyclophosphamide, doxorubicin, vincristine, and prednisone (CHOP) chemotherapy regimen.
Implications:
- This case expands the known spectrum of extranodal non-Hodgkin's lymphoma.
- Successful treatment with modified CHOP therapy suggests a potential therapeutic approach for this rare condition.
- Further research into primary duodenal ALCL is warranted to understand its pathogenesis and optimize management strategies.
Abstract:
As recently described, Ki-1 anaplastic large cell lymphoma is a distinctive subtype of non-Hodgkin's lymphoma. We report a Ki-1 anaplastic large cell lymphoma of the duodenum in a 62-year-old man. He received modified CHOP therapy and was in complete remission at 18 months. To our knowledge, this is the first report of primary Ki-1 anaplastic large cell lymphoma of the duodenum.
