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Updated: Aug 9, 2026
Multiplexed Fluorescent Immunohistochemical Staining, Imaging, and Analysis in Histological Samples of Lymphoma
Published on: January 9, 2019
Subcutaneous crystal-storing histiocytosis associated with lymphoplasmacytic lymphoma (immunocytoma)
O Kaufmann1, A Hansen, P Deicke
1Institute of Pathology, Charité University Hospital, Berlin, Germany.
Insights
This case study describes massive crystal-storing histiocytosis in a patient with lymphoplasmacytic lymphoma transforming into large cell lymphoma. The histiocytes contained immunoglobulin crystals, indicating a link between the lymphoma and crystal deposition.
Area of Science:
- Hematology
- Oncology
- Pathology
Background:
- Crystal-storing histiocytosis is a rare disorder characterized by the accumulation of immunoglobulin crystals within histiocytes.
- It is often associated with lymphoproliferative disorders, particularly B-cell lymphomas.
Abstract:
A case of massive crystal-storing histiocytosis with extensive involvement of the subcutaneous adipose tissue in a 61-year-old caucasian woman with a lymphoplasmacytic lymphoma (immunocytoma) in transformation to a large cell lymphoma is presented. Paraffin-section immunohistochemistry demonstrated a monoclonal IgM/ kappa immunphenotype of the lymphoma cells and revealed IgM/kappa and, to a lesser extent, IgG/lambda in the crystal-containing histiocytes. Ultrastructurally, the electron dense intracytoplasmic crystals had variables shapes, were occasionally membrane-bound and measured up to 6 microns. The finding are briefly discussed.
